摘要
目的以妊娠期血脂特异性参考区间作为判断依据,对妊娠期糖尿病(GDM)患者及其胎儿脐血的血脂状态进行更为科学地评估。方法选取该院定期产前检查直至分娩的GDM患者81例设为GDM组,健康对照组86例,GDM患者胎儿脐血65例及健康孕妇胎儿脐血47例。采用全自动生化分析仪检测总胆固醇(CHOL)、三酰甘油(TRIG)、高密度脂蛋白胆固醇(HDL)、低密度脂蛋白胆固醇(LDL)、载脂蛋白A1(ApoA)、载脂蛋白B(ApoB)和脂蛋白(a)[LP(a)]含量。分别采用本研究组建立的正常妊娠特异性血脂参考区间(PSR)及正常非孕参考区间(NPR)对GDM患者血脂状态进行评估比较,并随访妊娠结局。结果与健康对照组相比,GDM组ApoA、HDL、LDL显著降低(P<0.05);GDM脐血HDL、LDL、LP(a)显著降低(P<0.05)。以妊娠特异性参考区间作为判断标准,低水平HDL的GDM孕妇其子代新生儿体质量明显增高(P<0.05),高水平LDL的GDM子代出生体质量明显偏低(P<0.05),而用健康非孕参考区间评估无此发现。母体HDL与新生儿体质量无相关性(r=-0.190,P=0.103);母体LDH与新生儿体质量明显负相关(r=-0.252,P=0.029)。结论本研究所建立的健康妊娠特异性血脂参考区间对GDM孕妇及其胎儿脐血的血脂状态的评估具有重要意义。
Objective To assess lipid status of pregnant women with GDM based on the lipid reference intervals for pregnant women. Methods Maternal blood and venous cord blood samples were collected in 81 well-controlled GDM mothers and 86 control subjects. The total cholesterol （CHOL）, trigalloyl glycerol （TRIG）, high-density lipoprotein cholesterol （ HDL）, low-density lipo- protein cholesterol （LDL）, apolipoprotein A1 （ApoA）, apolipoprotein B （ApoB） and lipoprotein （a） levels were measured by auto- matic biochemical analyzer. We used a normal pregnancy specific lipid reference interval （PSR） and normal non-pregnant reference intervals （NPR） respectively to assess the lipid status of pregnant women with GDM. Results Compared with normal control group,the Apo A,HDL and LDL levels in GDM group were significantly lower （P〈0.05）. The HDL,LDL and Lp（a） levels of GDM cord blood were significantly lower （P〈0.05）. The weight of offspring birth of GDM pregnant women with low level HDL was significantly higher （P〈0.05）, and that of GDM pregnant women with high level LDL offspring birth weight was significantly lower （P〈0.05）. Maternal HDL was not correlated with birth weight （r=-0. 190, P= 0. 103）. Parent LDH and birth weight was negatively correlated （r= -0. 252,P= 0. 029）. Conclusion The reference range of normal pregnancy-specific lipid we had estab- lished is more scientific for assessment of blood lipids.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第21期2470-2472,2475,共4页
Chongqing medicine
基金
常州市卫生局重大科技项目(ZD201013)
关键词
糖尿病
妊娠
血脂
参考值范围
diabetes, gestational
blood lipids
reference interval
