摘要
目的探讨血清肌酐(Cr)、胱抑素-C(Cys-C)、尿素氮(BUN)及尿β2-微球蛋白(β2-MG)检测在2型糖尿病早期肾损伤中的检测价值。方法选择茂名石化医院2010年2月～2012年12月收治的2型糖尿病早期肾病损伤患者60例为研究组,根据尿清蛋白排泄率(UAER)将研究组患者分为正常蛋白尿组(UAER<30 mg/d,A组)18例、微量蛋白尿组(UAER 30～<300 mg/d,B组)20例和大量蛋白尿组(UAER≥300 mg/d,C组)22例,另选择60例健康者为对照组。检测所有研究对象的Cr、BUN、Cys-C及β2-MG;分析研究组BUN、Cys-C及β2-MG与Cr的相关性;比较研究组各项指标联合检测的阳性率。结果①研究组患者Cr、BUN、Cys-C和β2-MG均高于对照组,差异有统计学意义(P<0.05)。②A、B、C三组患者Cr、BUN、Cys-C和β2-MG之间,差异均有统计学意义(F=15.26、4.67、4.21、5.23,均P<0.05)。③研究组BUN与Cr呈正相关(r=0.622,P<0.05),Cys-C与Cr呈正相关(r=0.782,P<0.05),β2-MG与Cr呈正相关(r=0.645,P<0.05)。④Cr+BUN+Cys-C+β2-MG联合检测的阳性率为65.0%,明显高于三联检测和单独检测,差异有统计学意义(P<0.05)。结论患者的蛋白尿水平越高,各项指标的水平越高;Cr、BUN、Cys-C、β2-MG联合检测的阳性率较高,且是临床诊断的有效指标。
Objective To explore the test value of the serum creatinine,cystatin C,urea nitrogen and β2-microglobulin detection in the early renal damage in type 2 diabetes mellitus.Methods 60 cases of early renal damage in patients with type 2 diabetes were selected as the research group in Maoming Petrochemical Hospital from February 2010 to December 2010,they were divided into the normal albuminuria group with 18 cases（group A）,trace albuminuria group with 20 cases（group B） and massive proteinuria group with 22 cases（group C） according to the UAER,60 health cases were selected as the control group.The serum urea nitrogen（BUN）,creatinine（Cr）,cystatin-C（Cys-C）,and beta 2-microglobulin（β2-MG） were tested in all objects of the study;the correlation among Cr and BUN,Cys-C,β2-MG in research group were analyzed;positive rate of indicators joint detection in research group were compared.Results ①The serum Cr,Cys-C,BUN and β2-MG in research group were higher than that of the control group,the differences were statistically significant（P 0.05）.②The differences of Cr,BUN,Cys-C,β2-MG among the group A,group B,group C were statistically significant（F = 15.26,4.67,4.21,5.23,P 0.05）.③BUN and Cr was positively correlated（r = 0.622,P 0.05）;Cr and Cys-C were positively correlated（r = 0.782,P 0.05）;β2-MG and Cr were positively correlated（r = 0.645,P 0.05）.④Positive rate of Cr＋BUN＋Cys-C＋β2-MG joint detection was 65.0%,which was higher than the joint inspection and individually,the differences were statistically significant（P 0.05）.Conclusion The patient＇s level of proteinuria is higher,the level of the indicators are higher;positive rate joint detec tion of BUN,Cr,Cys-C and β2-MG are high,and they are effective indicators of clinical diagnosis.
出处
《中国医药导报》
CAS
2013年第22期94-96,共3页
China Medical Herald
