摘要
探讨桂西地区壮族鼻咽癌患者和健康人EB病毒EBNA1/IgA、EA/IgG及EA/IgA抗体在不同性别中的水平。收集140例未经治疗的壮族鼻咽癌患者和280例健康人的血清,用酶联免疫吸附法(ELISA)检测EBNA1/IgA、EA/IgG及EA/IgA抗体,分别计算各性别的抗体水平并进行统计学分析。健康人中男女EA/IgG、EA/IgA、EBNA1/IgA抗体rA值比较,差异无统计学意义(P<0.05)。鼻咽癌患者中,男性EA/IgG、EA/IgA抗体rA值大于女性,女性EBNA1/IgA抗体rA值大于男性(P<0.05)。男性和女性鼻咽癌患者3种抗体水平均高于相应健康人(P均小于0.05)。桂西地区壮族鼻咽癌患者EB病毒EBNA1/IgA、EA/IgA及EA/IgG抗体水平存在性别上的差异。在鼻咽癌的临床诊断和高危人群筛查中可能有必要根据不同性别的人群界定不同的阳性临界值。
To evaluate the relationship between gender and the levels of anti-Epstein-Barr virus （EBV） antibodies EBNA1/IgA, EA/IgG and EA/IgA rA value in nasopharyngeal carcinoma （NPC） patients and healthy population of Zhuang nationality in western Guangxi, serum samples obtained from 140 patients with NPC and 280 healthy subjects were examined for the presence of the EBV antibodies EBNA1/IgA, EA/IgG and EA/IgA by enzyme-linked immnunosorbent assay （ELISA）. The antibody levels in the NPC patients in different gender were analyzed statistically. No significant differences in EBNA1/IgA, EA/IgG and EA/IgA rA value were found between male and female in the healthy population （P〉0.05）. However, the values of EA/ IgG and EA/IgA in male patients were significantly higher than those in female patients （P〈0.05） . The value of EBNA1/IgA in female patients was significantly higher than that in male patients（P〈0.05）. The values of the 3 antibodies in NPC patients were significantly higher than those in the healthy population in both gender （P〈0.05）. The serum rA value of these 3 antibodies varied with gender. These results indicate that it would be imperative to set different critical values for EBV antibodies for different genders to facilitate NPC diagnosis and high-risk screening.
出处
《现代免疫学》
CAS
CSCD
北大核心
2013年第4期325-327,共3页
Current Immunology
关键词
鼻咽癌
EB病毒
抗体
性别
nasopharyngeal carcinoma
Epstein-Barr virus
antibody
gender
