期刊文献+

硫酸氢氯吡格雷与阿司匹林联用致血尿 被引量:3

Hematuria due to concomitant use of clopidogrel hydrogen sulfate and aspirin
原文传递
导出
摘要 1例57岁女性高血压病患者,长期口服阿司匹林、硝苯地平、富马酸比索洛尔,因冠状动脉粥样硬化性心脏病致心绞痛,加用硫酸氢氯吡格雷75 mg口服,1次/d;马来酸桂哌齐特320 mg,1次/d静脉注射。6 h后出现间歇性血尿,伴尿频、尿急、尿痛。尿常规检查示尿隐血(+++),红细胞17个/高倍视野(HP)。双肾、膀胱超声检查未见异常。停用硫酸氢氯吡格雷。次日,患者尿色逐渐恢复,尿隐血(++),红细胞4个/HP。3 d后尿常规检查正常。 A 57-year-old woman, who had 20 years history of hypertension, was treated with longterm use of oral aspirin, nifedipine, and bisoprolol fumarate. Oral elopidogrel hydrogen sulfate 75 nag once daily and an IV infusion of einepazide maleate 320 mg once daily were added to her regimen due to angina pectoris caused by coronary atherosclerotie heart disease. Six hours later, the patient developed intermittent hematuria, followed by urinary frequency, urinary urgency, and urodynia. Routine urine test showed occult blood ( + + + ) and 17 red blood eells/HP. Ultrasonography showed no abnormal changes in bilateral kidney and bladder. Clopidogrel hydrogen sulfate was withdrawn. The next day, her urine color was normalized gradually and routine urinalysis showed occult blood ( + + ) and 4 red blood eells/HP. Three days later, all results in the routine urine test was within normal range.
出处 《药物不良反应杂志》 CSCD 2013年第3期168-169,共2页 Adverse Drug Reactions Journal
关键词 阿司匹林 氯吡格雷 血尿 Aspirin Clopidogrel Hematuria
  • 相关文献

参考文献6

二级参考文献127

  • 1Anderson JL,Adams CD,Antman EM,et al.ACC/AHA2007 guidelines for the management of paints with unstable angina/non-ST-elevation myocardial infarction.J Am Coll Cardiol,2007,50(7):e1-e157
  • 2Bhatt DL,Scheiman J,Abraham NS,et al.ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use:a report of the American Documents.Circulation,2008,118(18):1894-1909
  • 3Gilard M,Arnaud B,Le Gal G,et al.Influence of omeprazol on the anpiplatelet action of clopidogroi associated to aspirin.J Thromb Hacmost,2006,4(11):2508-2509
  • 4Gilard M,Arnand B,Cornily JC,et al.Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin:the randomized,doublehlind OCLA(Omeprazole CLopidogrel Aspirin)study.J Am Coll Cardiol,2008,51(3):256-260
  • 5Food and Drug Administration.Early Communication about an ongoing safety review of clopidogrel bisulfate(marketed as Plavix).http://www.fda.gov/cder/drug/early comm/clopidogrel bisulfate.htm.Accessed January 26,2009
  • 6Ho P.M,Maddox MT,Wang L et al.Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndromes.JAMA,2009,301(9):937-944
  • 7Aubert RE,Epstein RS,Teasarden JR,et al.Abstract 3998:Proton pump inhihitors effect on clopidogrel effectiveness:the Clopidogrel Medco Outcomes Study.Circulation,2008,118(suppl.):S815
  • 8Juurlink DN,Gomes T,Ko DT,et al.A population-based study of the drug interaction between proton pump inhibitors and clopidogrel.CMAJ,2009,180(7):699-700
  • 9Geiger J,Brich J,Honig-Liedl P,et al.Specific impairment of human platelet P2Y(AC)ADP receptor2 mediated signaling by the antiplatelet drug clopidogrel.A rterioscler Thromb Vasc Biol,1999,19(8):2007-2011
  • 10Savi P,Pereillo JM,Uzabiega MF,et al.Identification and biological activity of the active metabolite of clopidogsel.Thromb Hacmest,2000,84(5):891-896

共引文献54

同被引文献20

引证文献3

二级引证文献6

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部