摘要
目的探讨孕中期(14～21周)妇女血清甲胎蛋白(AFP)和游离β-人绒毛膜促性腺激素(Free-βHCG)双联法检测在早期诊断唐氏综合征胎儿缺陷的临床应用价值。方法采用化学发光免疫分析法分别对1421例孕中期妇女血清进行AFP和Free-βHCG两项指标检测,结合妇女年龄、孕周、体质量等临床资料,通过配套的风险评估软件计算出该妇女的唐氏综合征(DS)风险率。对DS、18-三体综合征高风险的孕妇建议其进一步进行羊水穿刺产前诊断,对神经管缺陷(NTD)高风险的孕妇进行超声波检查确诊。结果在筛查的1421例孕妇中,高风险的孕妇为104例,阳性率为7.32%;其中DS高危78例占5.49%,经确诊有4例为阳性;NTD高危14例占0.99%,经确诊有2例为阳性;18-三体高危12例占0.84%,经确诊阳性率为0。结论利用孕中期妇女AFP和Free-βHCG两项指标的检测,有效地筛查出了本地区DS高风险孕妇,降低了DS缺陷儿的出生率,在减轻家庭及社会负担起到了重要的作用。
Objective Study of second lrimester（14-21weeks） women serum alpha-fetopmtein（AFP） and free beta human chorionic gonadotmpin（Free-βHCG） duplex assay in early diagnosis of fetal defects in Down,s syndrome clinical application value. Methods In 1421 pregnant women serum two indicators of AFP and Free-βHCG was detected by chemiluminescence immunoassay method, combined with clinical data, women,s age, gestational age, body weight, through the risk assessment software suppurting the calculation of the women of Down,s syndrome（DS） risk rate. On DS, 18-trisomy syndrome high risk pregnant women suggest the further amniocentesis in prenatal diagnosis of neural tube defects, （NTD）high risk pregnant women were ultrasonic diagnosed. Results In 1421 cases of women screening in high risk pregnant women, 104 cases, the positive rate was 7.32%; of which 78 cases of high-risk DS accotmted for 5.49%, confirmed 4 cases were positive; NTD 14 high risk cases accounted for 0.99%, confirmed 2 cases were positive rate of diagnosis 0. Conclusion Detection of two indexes by using the second trimester women AFP and Free-βHCG, effectively screening out the local area DS high risk pregnant women, reduces the DS of children with birth defects, to an important role in reducing the burden of family and society.
出处
《中国医药指南》
2013年第19期460-461,共2页
Guide of China Medicine
关键词
孕中期
甲胎蛋白
游离β-人绒毛膜促性腺激素
产前筛查
唐氏综合征
Second trimester
Alpha-fetoprotien
Free beta human chorionic gonadotropin
Prenatal screening
Down,s syndrome
