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氧化应激和泌乳素裂解与女性心功能不全的关系 被引量：2

Relationship between female cardiac insufficiency and oxidativestress as well as prolactin cracking
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摘要 氧化应激是心功能不全发生发展的重要机制之一。氧化应激导致组织蛋白酶D激活,组织蛋白酶D将泌乳激素由23kDa裂解为16kDa。16kDa泌乳素抑制血管内皮生成和促进细胞凋亡,与女性心功能不全有关。 Summary Oxidative stress is one of the important mechanisms in the occurrence and development of cardiac dysfunction. Oxidative stress causes cathepsin D activation, which in turn, makes prolactin crack from 23 kDa to 16 kDa. This cracked 16 kDa prolactin inhibits endothelial formation and promotes cell apoptosis, which is related with female cardiac dysfunction.
作者 王楠 李万鹏 周淑红
机构地区 甘肃省人民医院心内科 兰州大学第一临床医学院心内科 甘肃省人民医院内分泌科
出处 《临床心血管病杂志》 CAS CSCD 北大核心 2013年第7期483-485,共3页 Journal of Clinical Cardiology
关键词 氧化应激 泌乳素裂解 心功能不全 oxidative stress prolactin cracking cardiac insufficiency
分类号 R541.4 [医药卫生—心血管疾病]
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参考文献19

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二级参考文献21

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共引文献14

同被引文献7

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二级引证文献15

临床心血管病杂志
2013年 第7期

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