摘要
目的:评价工程牛黄组方的牛黄降压丸的降压作用,与原方剂进行疗效比较,为替代原组方中人工牛黄提供药效学依据。方法:采用自发性高血压大鼠(SHR)进行降压试验观察,分为模型对照组、原牛黄降压丸组和阳性药对照组,以及新组方牛黄降压丸80%,60%,30%,10%替代组。分别灌胃给予各受试药(给药剂量均为1.76 g.kg-1),连续给药14 d,采用ALC-NIBP无创血压测定分析系统,分别测定给药0,5 h,6,10,14 d,停药后3,7 d的血压情况。结果:给药5 h后,80%工程牛黄替代组出现明显降血压作用[收缩压(SBP,139.25±19.24)mmHg,舒张压(DBP,05.69±19.18)mmHg],与对照组[SBP(187.2±19.24)mmHg,DBP(123.76±18.43)mmHg]比较,具有统计学差异(P<0.05)。80%和60%工程牛黄替代组均于给药6 d表现出明显的降血压作用,与模型对照组比较SBP具有统计学差异(P<0.01),于给药6 d后各组降低DBP效果趋于稳定,以80%和60%工程牛黄替代组最为明显。停药后各受试组大鼠仍表现出明显的降压作用,以80%工程牛黄替代组降压效果最佳。80%和60%工程牛黄替代组具有明显的减慢心率的作用,此作用与工程牛黄含量比例成正比,而原组方未见该作用。结论:工程牛黄替代品的牛黄降压丸组方的降压作用优于原组方,具有用量少、起效快、作用强且作用持久的优点。
Objective： To compare the effect of engineering Niuhuang Jiangya capsule（ENJC） and artificial Niuhuang Jiangya capsule（ANJC） on blood pressure in spontaneously hypertension rats（SHR）.Method： SHR were randomly divided into 7 groups in accordance with the systolic blood pressure： model control group,ANJC group and enalapril control group,and ENJC groups（80%,60%,30%,10% alternated respectively）.SHR were given oral drug for 14 d accordingly.ALC-NIBP blood pressure monitoring system was employed to determine blood pressure before drug given and at 5 h,6,10,14 d after drug administration,the blood pressure of 3,7 d after drug application was also monitored.Result： After administration of 5 h,the rats of 80% ENJC showed significantly（P 0.05） reduced blood pressure [（SBP（139.25 ± 19.24） mmHg,DBP（105.69 ±19.18） mmHg],compared with the control group [（SBP（187.2 ±19.64） mmHg,DBP（123.76 ± 18.43） mmHg].On the 6 d of administration 80% and 60% ENJC showed significant antihypertensive effect,and the reduced DBP tended to be stable.After taking drug for 14 days,the hypotensive effect of 80% ENJC was most obvious.ENJC of 80% and 60% had significant effect of reducing heart rate.The function is proportional to the dose of ENJC.ANJC did not show the similar effect.Conclusion： Antihypertensive effect of ENJC is better than the original ANJC,with less dose,rapid onset and stonger and lasting effect.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第15期265-268,共4页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
工程牛黄
人工牛黄
牛黄降压丸
SHR
降血压
心率
engineering bezoar
artificial bezoar
Niuhuang Jiangya capsule
SHR
antihypertensive effect
heart rate
