摘要
目的:探讨数学建模策略在中药药性物质基础研究中的应用,并尝试建立一套客观可重复的建模思路与方法。方法:从数据库建立、数据预处理、建模策略选择和评价标准制定4个关键步骤,讨论中药药性特征标记识别模型的建立。结果:从64种建模策略中选出17种判别良好的模型,继而考察其可视化表达能力选出4种适宜模型,最后经统计模拟,选出PLS作为目前最适宜模型。结论:中药药性与其发挥作用的物质基础之间难以找到现成的公式或规律来表达二者关联,可用穷举策略,经数据库建立、数据预处理、建模策略选择和评价4步筛选适宜的中药药性特征标记识别模型。
Objective： To discuss the application of mathematical modeling strategies in material foundation of traditional Chinese medicine（TCM）,and try to establish a set of objective modeling methods.Method： From the database establishment,data preprocessing,modeling strategy choosing and model’s evaluations the most appropriate recognition model for CHMP-markers was choose.Result： Seventeen kind of modeling strategies from 64 was selected,and 4 kind was chosen in view of the visual expression ability,and PLS was selected as the most appropriate one via statistical simulation.Conclusion： It is difficult to find ready-made formula or law express the relation between the relation of Chinese medicine medicinal properties and material base,exhaustive method can be used to choose the most suitable model,database establishment,data preprocessing,modeling strategy choosing and model’s evaluations are the 4 key steps.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第15期337-339,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家重点基础研究发展计划项目(2007CB512601)
关键词
数学建模
药性
物质基础
穷举建模策略
mathematical modeling
Chinese medicine medicinal properties
material base
exhaustive method
