摘要
目的研究长期小剂量克拉霉素治疗慢性鼻-鼻窦炎的临床疗效。方法选取2010年8月至2012年10月在延安大学附属医院治疗的慢性鼻-鼻窦炎患者83例,随机分成实验组(42例)和对照组(41例)。实验组采用小剂量口服克拉霉素治疗12周,对照组采用口服阿莫西林克拉维酸钾治疗4周。经过治疗后对两组患者的症状、体征改善情况进行评估。结果实验组治愈27例,有效10例,总有效率为88.10%;对照组治愈21例,有效9例,总有效率为73.17%,两组总有效率差异有统计学意义(P<0.05)。不良反应:实验组出现恶心、腹痛和头痛患者各1例,不良反应发生率为7.14%(3/42);对照组出现恶心呕吐5例、腹泻3例、哮喘1例,不良反应发生率为21.95%(9/41),两组患者的不良反应发生率差异有统计学意义(P<0.05)。结论采用长期小剂量克拉霉素治疗慢性鼻-鼻窦炎疗效良好,药物不良反应安全耐受。
Objective To study clinical effects of long-term and low-dose clarithromycin in treatment of chronic rhinosinusitis.Methods 83 patients in Affiliated Hospital of Yan′an University for treatment of chronic rhinosinusitis from August 2010 to October 2012 year were randomly divided into experimental group（42 cases） and control group（41 cases）.The experimental group with small dose of oral clarithromycin for 12 weeks,control group with oral amoxicillin and clavulanate potassium for 4 weeks.Then the situation of signs and symptoms of the two groups were evaluated after treatment.Results 27 cases were cured,10 cases were effective,and the total effective rate was 88.10% in experimental group.21 cases were cured,9 casese were ffective,and the total effective rate was 73.17% in control group.The difference was statistically significant（P0.05）.The incidence of adverse reactions such as nausea,abdominal pain and headache patients was 1 case respectively in experimental group,and the incidence of adverse reaction was 7.14%（3/42）.Nausea and vomiting were 5 cases,diarrhea were 3 cases,asthma was 1 cases,and the incidence of adverse reaction was 21.95%（9/41） in control group.The difference was statistically significant（P0.05）.Conclusion Using small dose clarithromycin for long time in the treatment of chronic rhinosinusitis might have good curative effect,drug safety and tolerance.
出处
《检验医学与临床》
CAS
2013年第15期1968-1969,共2页
Laboratory Medicine and Clinic
关键词
克拉霉素
慢性鼻-鼻窦炎
长期小剂量治疗
clarithromycin
chronic rhinosinusitis
long term low dose treatment
