摘要
目的探讨腰椎间盘突出症中磷脂酶A2的表达及与神经根性疼痛的关系。方法选择80例腰椎间盘突出症伴神经根性疼痛患者,根据神经根性疼痛程度分为四组(Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级),每组20例。采用ELISA法检测腰椎间盘患者髓核组织中磷脂酶A2水平,分析后者与患者神经根性疼痛的关系。并取同期20例腰椎骨折手术患者正常腰椎间盘进行对照。结果①腰椎间盘突出症患者髓核组织磷脂酶A2的表达均比正常对照组增高(P<0.05);②腰椎间盘突出物中磷脂酶A2的表达随神经根性疼痛程度的加重而逐渐升高,即表现为IV级>Ⅲ级>Ⅱ级>Ⅰ级(P<0.05)。结论腰椎间盘突出症患者髓核组织磷脂酶A2的表达比正常椎间盘明显增加;髓核组织中磷脂酶A2水平增高可能在腰椎间盘突出神经根性疼痛中起重要作用。
Objective To explore the expression of Phospholipase A2（PLA2） in the nulcei pulposus of the lumbar disc herniation（LDH） and its relation to the sciatic pain.Methods Eighty patients diagnosised with LDH and another twenty patients diagnosised with bursting fracture of lumbar spine（BFLS） were selected.The LDH patients were divideded into four groups according to the severity of sciatic pain each contained 20 patients：Grade Ⅰ,Ⅱ,Ⅲ and Ⅳ.The PLA2 activity was detected by EIISA in the nulcei pulposus obtained at surgery for disc hernition.Another 20 normal nulcei pulposus from patients suffering from BFLS were obtained and analyzed by the same procedure as a control group.Results ①The level of PLA2 in LDH patients were higher than control group（P0.05）;②The level of PLA2 in LDH increased with the severity of sciatic pain.Conclusion The expression of PLA2 in the nulcei pulposus of LDH patients were significantly higher than the control group.The increase of PLA2 activity in the nulcei pulposus was well correlated with the severity of sciatic pain.
出处
《中外医疗》
2013年第18期26-27,共2页
China & Foreign Medical Treatment
