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Wnt11基因在肾脏的表达及意义 被引量：3

Expression and significance of WntU in kidney
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摘要 Wnt信号通路是近年来的研究热点，对细胞的增殖、分化和迁移起巨大的调节作用。Wnt信号通路包括经典Wnt信号通路和非经典Wnt信号通路。Wnt11是非经典Wnt信号通路上一个非常重要的信号分子，是肾脏发育的重要的因子，在胚胎后肾的发育中起着积极的调控作用，在成熟肾脏处于沉默状态。有研究表明其在肾脏纤维化中重新表达。该文就其在肾脏发育中的作用及其与肾脏纤维化的关系作一综述。 Wnt signaling pathways is a hot focus in recent years, which plays important regulatory roles in cell proliferation, differentiation and migration. Wnt signaling pathways include classical Wnt signaling path- ways and non classical Wnt signaling pathways. Wnt11 is a very important signal molecule in the nonclassical WNT signaling pathways and kidney development, which plays a positive regulatory effect in the development of kidney and become silent in mature kidney. Studies have shown that Wnt11 re-express in the renal fibrosis. This paper discusses the function of the Wnt11 in kidney development and the relationship between Wnt11 and renal fibrosis.
作者 南晓娟(综述) 吴玉斌(审校)
机构地区 中国医科大学附属盛京医院儿科
出处 《国际儿科学杂志》 2013年第4期352-354,共3页 International Journal of Pediatrics
关键词 Wnt11信号通路 肾发育 肾纤维化 Wnt11 signaling pathways Renal development Renal fibrosis
分类号 R334.1 [医药卫生—人体生理学]
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参考文献22

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二级参考文献7

共引文献3

同被引文献93

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国际儿科学杂志
2013年 第4期

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