摘要
目的探讨绝经后女性瘦组织(LM)、体脂量(FM)对骨强度的影响。方法 101例健康女性受试者(年龄61.3±7.1岁)行腰椎、髋部及全身双能X线吸收测量法扫描获取腰椎(LS_BMD)、股骨颈(FN_BMD)、全髋(TH_BMD)、全身骨密度(TB_BMD)及全身骨矿物质含量(TB_BMC)。结果年龄、绝经年龄、身高、体重与TB_BMD、TB_BMC、LS_BMD、FN_BMD、TH_BMD存在线性相关性,P均<0.05。LM及FM与TB_BMD、TB_BMC、LS_BMD、FN_BMD、TH_BMD存在轻～中度正相关性(r=0.219～0.580,P均<0.05)。逐步多元线性回归分析,校正FM则LM对上述骨强度指标的影响消失,只有FM进入回归模型,FM解释TB_BMD、TB_BMC、LS_BMD、FN_BMD及TH_BMD变量变化分别为26.1%、60.9%、13.1%、19.9%、16.1%。结论是FM而非LM决定绝经后女性骨强度。
Objective To investigate the effect of lean mass （LM） and fat mass （FM） on bone strength in postmenopausal women. Methods A total of 101 healthy postmenopausal women with mean age of 61.3±.1 years were included in this study. Bone mineral density of the lumbar spine （LS_BMD） , the femus （FN_BMD） , total hip （TH_ BMD） , total body （TB_BMD） , and total body bone mineral content （TB_BMC） were measured using dual energy X-ray absorptiometry. Results In univariate analysis, age, years since menopause, height, body weight, LM, and FM had linear correlation with TB BMD, TB_BMC, LS_BMD, FN_BMD, and TH_BMD （P 〈 0.05）. In multiple liner regression analysis, both LM and FM had low-moderate correlation with TB_BMD, TB_BMC, LS_BMD, FN_BMD, and TH_BMD. However, when both LM and FM were included in the multivariate regression model after controlling for confounders above, the relationship between LM and bone data disappeared while only FM was an independent predictor for bone strength （P 〈 0. 05）. Variation explained by FM for TB_BMD, TB BMC, LS_BMD, FN_BMD, and TH_BMD was 26.1% , 60.9% , 13.1%, 19.9%, and 16. 1%, respectively. Conclusion FM, but not LM, is independently associated with bone strength in postmenopausal women.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2013年第7期681-685,共5页
Chinese Journal of Osteoporosis
基金
国家自然科学基金项目资助(编号:81202809)
上海市教委基金项目资助(编号:2010JW53)
关键词
双能X线吸收测量法
骨密度
体成分
瘦组织
体脂
Dual energy X-ray absorptiometry
Bone mineral density
Body composition
Lean mass
Fat mass
