1Jee SH,Foong AW,Hur NW,et al. Smoking and risk for diabetes incidence and mortality in Korean men and women[ J]. Diabetes Care, 2010,33(12) :2567-2572.
2Bei^man BC, Perreault L, Hunerdosse D, et al. Novel and reversible mechanisms of smoking-induced insulin resistance in humans[ J]. Diabetes, 2012 ,61 (12) :3156-3166.
3Tatebe J,Morita T. Enhancement of TNF-a expression and inhibition of glucose uptake by nicotine in the presence of a free fatty acid in C2C12 skeletal myocytes[ J]. Horm Metab Res,2011,43( 1 ) :11-16.
4Soumaya K. Molecular mechanisms of insulin resistance in diabetes [J]. Adv Exp Med Biol,2012(771) :240-251.
5Rowland AF,Fazakerley DJ,James DE. Mapping insulin/GLUT4 cir-cuitiy[J]. Traffic,2011,12(6) :672-681.
2Leibowitz G, Cerasi E, Ketzinel-Gilad M. The role of mTOR in the adaptation and failure of beta-cells in type 2 diabetes[J]. Diabetes, 2008, 10(4): 157-169.
3Murakami M, Ichisaka T, Maeda M, et al. roTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells[J]. Mol Cell Biol, 2004, 24(15) : 6710-6718.
4Fingar DC, Blenis J. Target of rapamycin (TOR) : an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression [J]. Oncogene, 2004, 23 ( 18 ) : 3151-3171.
5Gao N, Flynn DC, Zhang Z, et al. GI cell cycle progression and the expression of G1 cyelins are regulated by PI3K/AKT/mTOR/ p70S6K1 signaling in human ovarian cancer cells [J]. Am J Physiol Cell Physiol, 2004, 287 ( 2 ) : C281-C291.
6Wu T, Mohan C. The AKT axis as a therapeutic target in autoimmune diaease[ J ]. Endocr Mrtab Immune Disord Drug Targets, 2009, 9(2) :145-150.
7Fingar DC, Blenis J. Target of rapamycin(TOR) :an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression [J]. Oncogene, 2004, 23 ( 18 ) : 3151-3171.
8Rowlnsky EK. Targeting the molecular target of rapamycin (roTOR) [J]. Curr Opin Oncol, 2004, 16(6) : 564-575.
9Danielpour D. Functions and regulation of transforming growth factor-beta(TGF-β) in the prostate[J]. Eur J Cancer, 2005, 41 (6) : 846-857.
10Goraksha-Hicks P, Rathmell JC. TGF-beta : a new role for an old AktTOR[J]. Dev Cell, 2009, 17(1) :6-8.