摘要
目的考察磺胺嘧啶银达克罗宁复层膜对大鼠浅Ⅱ度烫伤的药效学作用。方法 30只SD大鼠随机分为生理盐水组、磺胺嘧啶银膜剂组、磺胺嘧啶银达克罗宁复层膜剂组,每组10只。采用将大鼠脱毛区置于85℃恒温水浴中15 s的方法制成10%体表面积浅Ⅱ度烫伤模型,观察用药前后的心率、痛阈变化以及创面愈合时间、愈合率等。结果磺胺嘧啶银达克罗宁复层膜剂对大鼠心率的初期影响较小,之后心率略有下降。同时该膜剂还能显著提高痛阈。对于创面愈合的平均时间,磺胺嘧啶银达克罗宁复层膜相对于磺胺嘧啶银膜剂略显优势,前者为(19.5±1.02)d,后者为(21±1.18)d。在第20天,磺胺嘧啶银达克罗宁复层膜剂组烫伤大鼠的痊愈率为90%。结论磺胺嘧啶银达克罗宁复层膜剂在延续磺胺嘧啶银膜剂强效的皮肤烫伤修复作用的同时又具有镇痛、促进创面愈合的作用。
OBJECTIVE To explore the pharmacodynamies of silver sulfadiazine-dyclonine composite film for the treatment of superficial Ⅱ degree burn in rats. METHODS Thirty SD rats were randomly divided into normal saline group, silver sulfadiazine film group and silver sulfadiazine-dyclonine composite film group（ n = 10 in each group）. The hair removal area of rats was scalded in 85 ℃ water bath for 15s, producing superficial Ⅱ degree burn model. The heart rates before and after the medication, changes of pain threshold, wound healing and cure rate were observed. RESULTS Silver sulfadiazine-dyelonine composite film had little influence on the heart rate in the early period, however, the heart rate decreased slightly soon afterwards. Silver sulfadiazine-dyclonine composite film increased the pain threshold significantly. Compared to silver sulfadiazine film, silver sulfadiazine-dyclonine composite film had a little advantage on the average time for wound healing which were （ 19. 5 ± 1.02） d for the composite film and （21 ± 1.18 ） d for the other one. On the 20th day, the cure rate of silver sulfadiazine-dyclonine composite film was 90%. CONCLUSION Silver sulfadiazine-dyclonine composite film also has skin burn repair action as silver sulfadiazine film, and it has analgesis effect and can promote wound healing.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2013年第15期1271-1274,共4页
Chinese Pharmaceutical Journal
基金
南通市科技计划项目(BK2011061)
关键词
磺胺嘧啶银达克罗宁复层膜
浅Ⅱ度烫伤
心率
痛阈
silver sulfadiazine-dyclonine composite film
superficial Ⅱ degree burn
heart rate
pain threshold
