摘要
目的:研究分析甲氨蝶呤联合来氟米特对类风湿性关节炎治疗的有效性和安全性,以更好地为类风湿性关节炎进行治疗给予参考。方法:选择2010年10月-2012年11月笔者所在医院收治的70例类风湿性关节突患者作为研究对象,随机分为两组。对照组患者给予来氟米特治疗,试验组患者使用甲氨蝶呤联合来氟米特治疗,观察对比两组患者治疗后的疗效和不良反应。结果:试验组经过治疗后,总有效率为85.71%,高于对照组,差异有统计学意义(P<0.05);试验组治疗后晨僵、握力、关节肿胀数、关节肿胀指数、关节压痛数和压痛指数等均有明显改善,与对照组比较差异有统计学意义(P<0.05)。试验组与对照组不良反应比较,差异无统计学意义(P<0.05)。结论:在临床工作中使用甲氨蝶呤与来氟米特联合对类风湿性关节炎患者进行治疗的效果较好,安全性较高,是一种有效的治疗方案。
Objective： To study the analysis of methotrexate and leflunomide on the efficacy and safety of the treatment of rheumatoid arthritis patients to better treatment for rheumatoid arthritis give reference.Methods： Rheumatoid facet from October 2010 to November 2012 in our hospital, 70 patients for the study were randomly divided into two groups.The control group were treated with leflunomide treatment, the experimental group patients with methotrexate and leflunomide treatment was observed, comparing the efficacy and adverse reactions of two groups after treatment.Results： Experimental group after treatment, the total effective rate of 85.71%, was higher than that in the control group（P〈0.05）; Experimental group patients after treatment of morning stiffness, grip strength, number of swollen joints, joint swelling index, joint tenderness andtenderness index showed significant improvement compared with the control group, the difference was statistically significant（P〈0.05）.Adverse reactions in patients for the experimental group and the control group comparison, the difference was statistically significant（P〈0.05）.Conclusion： The effect of combined treatment of patients with rheumatoid arthritis in clinical work with methotrexate and leflunomide better security, is an effective treatment plan.
出处
《中外医学研究》
2013年第22期21-23,共3页
CHINESE AND FOREIGN MEDICAL RESEARCH
