摘要
目的研究两种半胱氨酸衍生物对辐射损伤小鼠的保护作用。方法采用小鼠30 d存活率和外周血液学、免疫系统指标考察两种半胱氨酸衍生物(编号为化合物1、化合物2)对辐射损伤小鼠的保护作用。结果化合物1以150 mg.kg-1的剂量腹腔注射,可使小鼠存活率提高25%,其保护指数为1.34;白细胞数(WBC)、股骨有核细胞数(BMNC)、股骨DNA含量与空白对照组比较,差异有统计学意义。化合物2以400 mg.kg-1的剂量灌胃,可使小鼠存活率提高33.3%,延长小鼠的存活时间,其保护指数为1.36;WBC、BMNC、脾结节数、脾指数和胸腺指数与空白对照组比较,差异有统计学意义。结论两种半胱氨酸衍生物对辐射损伤小鼠有较好的保护作用。
Objective To investigate the radioprotective effect of two derivatives of cysteine. Methods A 30-day survival assay and the hematological,immunological parameters were adopted to explore radioprotective effect. Results Mice were treated with the two compounds once daily for three consecutive days before irradiation. When the mice were treated with continuous intraperitoneal injection of 150 mg · kg-1 body weight of compound 1, the survival rate was 25% higher than that in the radiation group, and the protection index was 1.34. White blood cells （ WBC ） , the number of nucleated cells in bone marrow （ BMNC ） , DNA content of femur were significantly different from those of the blank group. When the mice received continuous intragastric administration of 400 mg · kg-1 body weight of compound 2, the survival rate was 33.3% higher than that of the radiation group,and the protection index was 1. 36. The number of nucleated ceils in BMNC, WBC, spleen colony-forming units （CFU-S） and the thymus index, spleen index were significantly different from those in the blank group. Conclusion The two derivatives of cysteine can reduce the radiation-induced injury in mice.
出处
《医药导报》
CAS
北大核心
2013年第8期996-998,共3页
Herald of Medicine
关键词
半胱氨酸衍生物
存活率
血液学指标
免疫学指标
Cysteine derivative
Survival rate
Hematological parameters
Immunological parameters
