摘要
[目的]探讨人乳头状瘤病毒(HPV)感染与宫颈病变的关系。[方法]对2010年1月至2012年12月就诊的2423例病例进行液基细胞学检查和HPV检测,对细胞学诊断≥ASCUS及HPV检测为高危阳性的病例进行阴道镜下宫颈组织活检。[结果]在2423例病例中,HPV阳性率为36.11%(875/2423)。在ASCUS、LSIL、HSIL、SCC中HPV阳性率分别为54.13%、71.67%、93.85%和100.00%。组织学诊断CINⅠ、CINⅡ、CINⅢ、SCC病变中HPV阳性率分别为76.74%、85.0%、90.91%和100.00%。HPV16的检出率在不同宫颈病变中均居首位,且随宫颈病变的级别升高而感染率升高。[结论]HPV16是最常见的高危型。HPV检测并联合液基细胞学和组织学检查能更有效地筛查宫颈病变,为预防宫颈癌提供可靠的科学依据。
Purpose To explore the relationship of human papillomavirus（HPV） infection and cervical lesion. MethodsA total of 2 423 women in clinic from Jan,2010 to Dec,2012 were examined by HPV test and ThinPrep cytology test. Colposcopy and biopsy were underwent in the case of cytology results showed ASCUS or severe and high risk HPV positive.Results Of 2 423 cases,HPV positive rate was 36.11%（875/2423）。 HPV positive rate was 54.13%、71.67%、93.85% and 100.00% in patients with ASCUS,low grade squamous intraepithelial lesion, high grade squamous intraepithelial lesion and squamous cell carcinoma （SCC） respectively. Positive rate of HPV in CIN Ⅰ,CIN Ⅱ,CIN Ⅲ, SCC was 76.74% 、85.0% 、90.91% and 100.00% respectively.The HPV16 positive rate ranked the first in various cervical lesions,and the HPV 16 positive rate increased with the increase of grade of cervical lesions.Conclusions HPV16 is common subtype in cervical lesions. Combined with Thin- Prep cytology test and histology examination could be more easily and effectively in the screening of cervical lesions,thus offering reliable scientific bases for clinical prevention and treatment for cervical cancer.
出处
《中国肿瘤》
CAS
2013年第7期543-546,共4页
China Cancer
关键词
宫颈病变
HPV分型
液基细胞学
cervix lesion
human papillomavirus genotype
ThinPrep cytology test
