摘要
目的优选黄蒲通窍胶囊中石菖蒲、益智仁、川芎混合挥发油的最佳提取和包合工艺。方法采用水蒸气蒸馏法,运用正交试验,以挥发油提取量为指标,从加水量、浸泡时间、提取时间3个方面优选挥发油的最佳提取工艺;采用饱和水溶液法,运用正交试验,以包合物收率和挥发油包合率为指标,从挥发油与β-环糊精(β-CD)的比例、包合时间、包合温度3个方面优选最佳包合工艺。结果最佳提取工艺为:加入8倍量水,浸泡2 h,提取7 h;最佳包合工艺为:挥发油与β-CD的比例为1∶10,包合3 h,包合温度为40℃。结论优选的提取工艺收油率较高,包合工艺的挥发油包合率也较高,工艺稳定可行。
Objective To optimize the extraction and inclusion process of mixed volatile oil of Rhizoma acori graminei,Fructus alpiniae oxyphyllae and Rhizoma chuanxiong in Huangpu Tongqiao Capsules.Methods With steam distillation method,extraction amount as indicator,the orthogonal experiment was used to optimze the extraction process of volatile oil from three factors such as water amount,soak time and extraction time.With saturated aqueous solution method,co-inclusion compound yield and volatile oil rate as indicators,the orthogonal experiment was used to optimize the inclusion process from three factors such as the proportion of volatile oil and β-CD,inclusion time and inclusion temperature.Results The optimum extraction was：adding eight times amount of water and soak for 2 hours to extract 7 hours.The optimum inclusion process was：the proportion of volatile oil and β-CD was 1：10,the inclusion time was 3 hours,the inclusion temperature was 40 ℃.Conclusion Optimal extraction process of oil has higher rate,and the volatile oil inclusion rate of inclusion process was also higher,the process is stable.
出处
《中国中医药信息杂志》
CAS
CSCD
2013年第8期61-63,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
安徽中医药大学临床科学研究基金(2010LC-017A)
关键词
黄蒲通窍胶囊
挥发油
正交设计
提取工艺
包合工艺
Huangpu Tongqiao Capsules
volatile oil
orthogonal design
extraction process
inclusion process
