摘要
目的探讨西药联合参附注射液、川芎嗪防治糖尿病的效果。方法选取2010年6月至2011年6月遵化市中医医院内科收治的90例2型糖尿病患者,按随机数字表法分为观察组和对照组进行疗效观察,每组45例。所有患者根据血糖情况给予注射胰岛素或口服降糖药的常规治疗,观察组在此基础上联合参附注射液、川芎嗪治疗,比较防治糖尿病的效果。结果观察组总有效率为95.56%,对照组总有效率为77.78%,观察组总有效率显著高于对照组(χ2=6.15,P<0.05)。治疗后空腹血糖、餐后2 h血糖水平,观察组较对照组显著降低,分别为[(6.12±0.33)vs(6.97±0.27)mmol/L]、[(6.4±2.4)vs(8.4±2.6)mmol/L],差异有统计学意义(t=4.51,4.34,P<0.05);治疗后观察组红细胞醛糖还原酶、糖化血红蛋白水平均较对照组显著降低(t=4.60,5.16,P<0.05)。对照组治疗前后纤维蛋白原、血浆黏度无显著变化,而观察组治疗后较治疗前显著降低,且显著低于对照组(t=4.03,3.98,P<0.05)。观察组糖尿病发生率为17.78%,对照组为44.44%,差异有统计学意义(χ2=7.92,P<0.05)。结论西药联合参附注射液、川芎嗪能显著提高疗效,减少糖尿病慢性并发症的发生,值得临床推广应用。
Objective To investigate the effect of western medicine combined with shenfu injection and ligustrazine on preventing and curing chronic complications of diabetes.Methods From June 2010 to June 2011,90 patients with type 2 diabetes from Zunhua City TCM Hospital were divided into the observation group and control group according to the random number table,with 45 cases in each group.The control group were given insulin injection or oral hypoglycemic agents,and the observation group was also given shenfu injection and ligustrazine based on the control group treatment.Results The total effective rate of the observation group was 95.56%,which was 77.78% in the control group,the difference was statistically significant（χ2 = 6.15,P 0.05）.After treatment,the FPG and PBG2h were[（6.12 ± 0.33） vs（6.97 ± 0.27） mmol/L],[（6.4 ± 2.4） vs（8.4 ± 2.6） mmol/L],difference with statistical significance（t = 4.51,4.34,P 0.05）.In the control group,the Fib and ηp had no significant changes（t = 4.60,5.16,P 0.05）,which were significantly reduced than before treatment in the observation group,and significantly lower than that of control group（t = 4.03,3.98,P 0.05）.Chronic complications incidence of the observation group was 17.78%,which was 44.44% in the control group,the difference was statistically significant（χ2 = 7.92,P 0.05）.Conclusion Western medicine combined with shenfu injection and ligustrazine can significantly improve the efficacy and reduce the chronic complications of diabetes,thus is worthy of clinical application.
出处
《医学综述》
2013年第14期2673-2675,共3页
Medical Recapitulate
关键词
糖尿病
慢性并发症
参附注射液
川芎嗪
Diabetes
Chronic complications
Shenfu injection
Ligustrazine
