摘要
目的 采用HPLC测定宣肺祛痰口服液中盐酸麻黄碱的含量。方法 用氰基键合硅胶柱分离盐酸麻黄碱 ,流动相 :水 二正丁胺 磷酸 ( 10 0 0∶0 .18∶2 .4) ;检测波长 2 10nm。结果 理论塔板数按盐酸麻黄碱计算为 780 0 ;线形范围 0 .1～ 0 .6 μg(r =0 .9998) ;平均回收率为 96 .2 3 % ,RSD =0 .98% (n =5 )。结论 方法简便、快速、准确 。
OBJECTIVE To evaluate the quality of Xuanfei Qutan oral liquor.The contents of ephedrine hydrochloride in Xuanfei Qutan oral liquor was determined by HPLC.METHODS Ephedrine hydrochloride was separated on ZorbaxCN column and detected at 210 nm,by using waterDibutylaminephosphoric acid (1000∶0.18∶2.4) as the mobile phase.RESULTS The resolution was greater than 1.The number of the oretical plates calculated for ephedrine hydrochloride peak was 7800.The standard curve was liner over the range of 0.1～0.6 μg with the correlation coefficient 0.9998.The average recovery was 96.23% with RSD=0.98%(n=5).CONCLUSION The method is simple and fast,and can be used for the quantitative analysis of Xuanfei Qutan oral liquor.
出处
《中国药学杂志》
EI
CAS
CSCD
北大核心
2000年第8期548-550,共3页
Chinese Pharmaceutical Journal
