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血清IL-1β、IL-6及IL-10对急性胰腺炎预后判断的研究 被引量:11

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摘要 目的本实验通过检测急性胰腺炎(AP)患者血清促炎细胞因子白细胞介素-1β(interleukin-1β,IL-1β)和白细胞介素-6(interleukin-6,IL-6)及白细胞介素-10(interleukin-10,IL-10)水平,并结合患者的康复周期,了解抗炎及促炎细胞因子水平在病程中的变化及意义,探讨其对预后判断的预测作用。方法选取发病时间不超过1 d的急性胰腺炎病人,按照有无器官功能障碍或局部并发症,APACHEⅡ评分小于或大于8分,CT分级为A、B、C、D级,分为重症急性胰腺炎和轻型急性胰腺炎,重症急性胰腺炎(SAP)抽取入院后SAP患者于入院后第1、3、7、10、14天空腹抽取外周血,轻型急性胰腺炎(MAP)患者由于康复周期较短,住院时间较短则于1、3、7、10 d空腹抽取外周,用于检测血清IL-1、IL-6及IL-10水平。结果促炎-抗炎细胞因子二者之间的动态平衡在AP的发生和发展中起着重要的作用,二者的作用结果决定了胰腺炎的转归,治疗SAP的重点在于快速使二者达到低水平的动态平衡,加强对二者的检测,尤其是IL-6及IL-10的检测,有重要意义。结论促炎—抗炎细胞因子检测可广泛应用于临床。
出处 《安徽医药》 CAS 2013年第7期1185-1187,共3页 Anhui Medical and Pharmaceutical Journal
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参考文献11

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