摘要
目的 :探讨舒筋灵、唛酚生、地西泮三种中枢性肌松剂对杀虫单 (SCD)急性中毒的解救效果。方法 :采用 Bliss法测定 L D5 0 ,并进行其显著性测定。结果 :三种肌松剂能提高小鼠 SCD急性中毒 L D5 0 3～ 4倍 ,差异非常显著 ,二疏基丙磺酸钠 (DMPS)与肌松剂合用效果更佳。先给中枢性肌松剂对大鼠 SCD急性中毒有良好的保护作用。结论 :SCD经口染毒主要是引起中枢性兴奋致惊厥最后衰竭而死。单用中枢性肌松剂有良好的拮抗作用 ,如合用
Objective:To explore the effectiveness of 3 CNS muscular relaxants in relieving acute poisoning of SCD and its relief mechanism.Methods:LD 50 and the significant difference were doing by way of Bliss.Results:3 CNS muscular relaxants can raise 3～4 times LD 50 of mice by SCD.The difference is significant. The CNS muscular relaxants can relieve acute poisoning of rats by SCD.Better effect is obtained by the muscular relaxants with combined administration of DMPS.Conclusion:SCD by mouth causes death due to CNS convulsion. The CNS muscular relaxants are antidotal. Better effect is obtained with combined administration of DMPS.[FK(WB80011。6]
出处
《温州医学院学报》
CAS
2000年第3期188-189,共2页
Journal of Wenzhou Medical College
关键词
舒筋灵
唛酚生
地西泮
杀虫单中毒
SCD
methocarbamol
diazepam
DMPS
CNS muscular relaxants
