摘要
目的:观察中药灌肠对溃疡性结肠炎(UC)患者血清细胞因子可溶性白细胞介素-2受体(sIL-2R)及循环免疫复合物(CIC)的影响。方法:将入选的80例UC患者随机分为对照组和研究组,研究组患者给予中药保留灌肠,对照组患者给予柳氮磺胺吡啶治疗,两组疗程均为20d,分别采用ELISA法和放射免疫法检测患者治疗前、后血清sIL-2R和CIC水平及变化。结果:重度、中度和轻度UC患者血清sIL-2R、CIC水平变化比较差异均有统计学意义(P<0.05),治疗20d后,研究组患者治疗前和治疗后血清sIL-2R、CIC水平变化比较差异有统计学意义(P<0.05),研究组患者治疗后血清sIL-2R、CIC水平与对照组治疗后比较差异有统计学意义(P<0.05)。结论:细胞因子与UC患者发病密切相关,中药灌肠可以明显改善UC患者血清sIL-2R、CIC水平,值得临床推广应用。
Objective：To observe the effect of traditional Chinese medicine enema on serum cytokines（sIL-2R）and circulating immune complex（CIC）in patients with ulcerative colitis（UC）.Methods：A total of 80patients with UC were randomly divided into control group and research group.Patients in research group were given Chinese medicine retention enema,and patients in the control group were given salicylazosulfapyridine treatment.The course was 20days.ELISA and RIA methods were used respectively to detect the serum sIL-2Rand CIC levels.Results：There were significant differences in serum sIL-2R and CIC levels′among severe,moderate and mild UC patients（P0.05）.After treatment for 20days,there were significant differences in serum sIL-2Rand CIC levels before and after treatment in research group（P0.05）,and the differences in serum sIL-2R,CIC levels between research group and control group after treatment was statistically significant（P0.05）.Conclusion：Cytokines is closely associated with the UC development.Traditional Chinese medicine enema can obviously lower the serum sIL-2Rand CIC levels.It was worthy clinical application.
出处
《海南医学院学报》
CAS
2013年第9期1267-1269,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210789)~~
