摘要
目的:探讨ACS患者PCI术后血小板CD40L表达及血浆MPO水平的变化以及阿托伐他汀对二者的影响。方法:126例急性冠脉综合征患者随机分40mg治疗组、20mg对照组,分别于术前、术后第1天、7天、1个月空腹检测血清中MPO和sCD40L的水平。结果:(1)ACS发生后血液中sCD40L、MPO会迅速升高,在PCI的影响下,两者继续升高,然后逐渐下降。(2)治疗组PCI术后血清sCD40L、MPO水平的水平明显低于对照组,有统计学差异(P<0.05)。(2).sCD40L与MPO的变化趋势的相关性分析无相关性(P=0.58,r=0.153),结论:PCI术后患者血清炎性因子sCD40L、MPO进一步升高;阿托伐他汀对ACS患者PCI后血清sCD40L、MPO有明显的抑制作用。
Objective：To observe the changes of serum sCD40Land MPO levels in acute coronary syndrome（ACS）patients after undergoing percutaneous coronary intervention（PCI）and the influence of atorvastatin on serum sCD40Land MPO.Methods：A total of 126patients with acute coronary syndrome were randomly divided into atorvastatin（40mg）group and the control group（atorvastatin,20mg）.Blood samples were collected to detect serum sCD40Land MPO levels before and 1,7days and 1month after undergoing PCI.Results：1.The serum levels of sCD40Land MPO increased significantly in acute coronary syndrome patients after undergoing PCI,but after the increase,both levels decreased.2.The serum levels of sCD40Land MPO in the atorvastatin group were significantly lower than that in the control group（P 0.05）.No correlation between MPO and the changing tendency of sCD40Lwas found（P0.05;r=0.153）.Conclusion：The serum levels of sCD40Land MPO after undergoing PCI have increased significantly.2.Atorvastatin could significantly restrain the serum sCD40Land MPO levels for patients with acute coronary syndrome after undergoing PCI.
出处
《海南医学院学报》
CAS
2013年第10期1401-1405,共5页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210814)~~
