摘要
目的:探讨米非司酮联合利凡诺用于中期引产的疗效及对孕妇血清激素水平的影响。方法:将来我院要求进行终止妊娠的中期妊娠孕妇随机分成两组,对照组和观察组各52例,对照组采用单独使用利凡诺引产,观察组则采用利凡诺联合米非司酮引产。比较两种引产方法对孕妇血清激素水平和血流动力学指标影响的差异,统计两种方法的疗效差异。结果:术前两组间各项激素水平均无统计学差异(P>0.05);注射利凡诺24h后,观察组泌乳素、雌二醇、孕酮及VEGF水平显著低于对照组,而IG-FBP-1则高于对照组,差异具有统计学意义(P<0.05)。除术中观察组血氧饱和度高于对照组,差异具有统计学意义(P<0.05),其余血流动力学指标组间差异均无统计学意义,但观察组的波动较小。观察组宫缩发动时间和总产程显著低于对照组,产后2h出血量少于对照组,差异具有统计学意义(P<0.05)。观察组术中疼痛情况明显轻于对照组。结论:米非司酮联合利凡诺用于中期引产,对血清激素的影响大于利凡诺单用,而且对患者生命体征影响较小,引产效果更优。
Objective：To investigate the clinical effect of mifepristone combined with rivanol on midtrimester induction of labor and on levels of hormone in pregnant women.Methods：Women with midtrimester of pregnancy admitted from February 2011to October 2012were randomly divided into control group（induced labor by rivanol,n=52）and observation group（induced labor by mifepristone combined with rivanol,n=52）.Serum levels of hormone,haemodynamic indexes and the clinical effect of two groups were compared.Results：There was no difference in serum levels of hormone between two groups before induced labor.But 24hafter injection of rivanol,the serum levels of prolactin,estradiol,progesterone were significantly lower in observation group,the levels of IGFBP-1was significantly higher than control group（all P0.05）.There was no statistical difference in hemodynamic indexes between two groups,except for oxygen saturation which was significantly higher than control group during surgery.The starting time of contractions,total stage of labour and 2hpost-partum bleeding amount of observation group were significantly less than control group（all P0.05）.Conclusion：Mifepristone combined with rivanol is more effective in midtrimester induction of labor.The influence on levels of hormone was more significant than rivanol only.It has few influence on vital signs,and has better effect on induced abortion.
出处
《海南医学院学报》
CAS
2013年第10期1448-1451,共4页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210825)~~
关键词
米非司酮
利凡诺
中期引产
激素
Mifepristone
Rivanol
Midtrimester induction of labor
Hormone
