摘要
目的:观察温阳益气活血方对初发2型糖尿病患者早期糖尿病肾病(DN)的预防作用。方法:将244例患者用随机数字法分为两组各122例,对照组采取基础治疗,控制血糖、血压和血脂。治疗组在对照组的基础上加用温阳益气活血方。治疗前后检测红细胞压积(HCT)、全血比黏度(RBV)、血浆比黏度(RPV)、纤维蛋白原(FIB)及C反应蛋白(CRP)。随访3个月,观察早期糖尿病肾病新发率。结果:治疗过程中治疗组脱落15例,对照组脱落12例,实际有效病例217例。治疗3个月后,两组HCT、RBV、RPV、FIB及CRP较治疗前改善,差异均有显著性意义(P<0.05);治疗组HCT、RBV、RPV、FIB及CRP较对照组下降,差异均有显著性意义(P<0.05)。6个月内,治疗组早期DN的新发病率为6.36%,明显低于对照组(14.95%),差异有显著性意义(P<0.05)。结论:温阳益气活血方对初发2型糖尿病患者早期糖尿病肾病(DN)有一定的预防作用。其机制可能与降低血液黏度,改善血液流变学和血管微循环,同时具有一定的抗炎作用有关。
Objective：To observe the preventive effect of Wenyang Yiqi Huoxue Decoction on early diabetic nephropathy （EDN） in the incipient type 2 diabetes mellitus （T2DM）. Methods ：Two hundred and forty -four qualified patients were random- ized into the treatment group and the control group with digital sorting method by digital sorting method. Both groups received rou- tine basic treatment consisting of controlling blood sugar, blood pressure and blood fat, and additionally the treatment group re- ceived oral use of Wenyang Yiqi Huoxue Decoction. The changes of hematokrit （HCT） , fibrinogen （ FIB ） , C - reactive protein （CRP） as well as relative viscosity of whole blood （RBV） and plasma （RPV） were observed before and after treatment. A3 - month follow-up was carried out to observe the newly morbidity of early diabetic nephropathy. Results ： After continuously 3 - month treatment, there were effectively 217 cases with 15 come - off cases in the treatment group and 12 come - off cases in the control group. HCT, RBV, RPV, FIB and CRP were much improved in both groups （ P 〈 0. 05 ） and the improvement was obvious in the treatment group（P 〈0. 05） . In the during of six months, the occurrence rate was 6.36% in the treatment group and 14.95% in the control group, and the difference was significant between the two groups （P 〈 0. 05 ）. Conclusion ： Wenyang Yiqi Huoxue De- coction is effective for preventing EDN, which possibly combined with the reduced blood viscosity, the improvement of blood rhe- ology and vascular microcirculation, as well as a certain anti - inflammatory effect.
出处
《辽宁中医杂志》
CAS
2013年第8期1601-1603,共3页
Liaoning Journal of Traditional Chinese Medicine
关键词
2型糖尿病
初发
糖尿病肾病
中医疗法
温阳益气活血方
type 2 diabetes mellitus
primary attack
diabetic nephropathy
traditional Chinese medicine therapy
WenyangYiqi Huoxue Decoction
