摘要
目的:探讨炎琥宁对小儿支原体肺炎患者抗炎、促炎因子及免疫功能的影响。方法:将2012年3月至2013年1月于本院进行治疗的90例小儿支原体肺炎患者随机分为对照组(阿奇霉素组)45例和观察组(阿奇霉素联合炎琥宁组)45例,然后将两组患者治疗前与治疗后3 d、10 d的血清者抗炎因子(IL-2、IL-4、IL-10)、促炎因子(IL-6、TNF-α、IFN-γ)、细胞及红细胞免疫指标(CD3+、CD4+、CD8+及RBC-C3bR、RBC-ICR)进行比较。结果:观察组治疗后的3 d与10 d时的血清者抗炎因子、促炎因子、细胞及红细胞免疫指标的变化均明显大于对照组,并且观察组治疗前至治疗后3、10 d均呈现持续改善,均P<0.05,差异均有显著性。结论:炎琥宁对小儿支原体肺炎患者抗炎因子、促炎因子及免疫功能的影响较大,对于患儿的炎性及免疫状态的改善作用均相对明显。
Objective To study the effects of Yanhuning on the anti-inflammatory and pro-inflammatory cytokines and immunological function of children with mycoplasma pneumonia. Methods 90 children with mycoplasma pneumonia in our hospital from March 2012 to January 2013 were randomly divided into control group （azithromycin group, 45 cases） and observation group （azithromycin combined with Yanhuning group, 45 cases） ; then the serum anti-inflammatory and pro-inflammatory cytokines （IL-2, IL-4, IL-10; IL-6, TNF-et, IFN-γ）, cellular immunity and erythrocyte immunity of the two groups （CD3＋, CD4＋, CD8＋ , RBC-C3bR, RBC-ICR） before the treatment and at 3rd and 10th day after the treatment were compared. Results The changes of serum antiinflammatory and pro-inflammatory eytokines, cellular immunity and erythroeyte immunity at 3rd and 10th day after the treatment in observation group were all obviously bigger than those in control group; and those indexes in observation group from before the treatment to at 3rd and 10th day after the treatment showed continuous improvement （all P 〈 0.05）. Conclusion Yanhuning had influence on the anti-inflammatory and pro-inflammatory cytokines and immunological function of children with mycoplasma pneumonia, and had obvious improving effect on their inflammatory and immune state.
出处
《实用医学杂志》
CAS
北大核心
2013年第16期2608-2610,共3页
The Journal of Practical Medicine
关键词
小儿支原体肺炎
炎琥宁
抗炎因子
促炎因子
免疫
影响
Children with mycoplasma pneumonia
Yanhuning
Anti-inflammatory cytokines
Pro-inflammatory cytokines
Immune
Influence
