摘要
目的:探讨中药四黄虎胶囊对豚鼠生殖器疱疹病毒感染后细胞因子IL-2、IL-6以及TNF水平的影响。方法:将四黄虎胶囊用于治疗感染生殖器疱疹病毒的豚鼠模型,与阳性药物阿昔洛韦(ACV)对照,感染病毒后第12天测定豚鼠体内细胞因子IL-2、IL-6以及TNF水平。结果:四黃虎胶囊有明显提高IL-2的作用;病毒感染后,豚鼠的IL-6水平均降低,其中以ACV组及四黃虎大剂量组下降的最多,有显著性差异。ACV组及四黃虎各剂量组的TNF的水平均升高,与模型组比较,ACV组及四黃虎各剂量组的TNF的水平亦高。但各组TNF水平,P>0.05,无显著性差异。结论:中药四黄虎胶囊对豚鼠生殖器疱疹病毒感染后细胞因子IL-2、IL-6以及TNF水平具有一定的调节作用。
Objective： To study the effect of capsule Sihuanghu containing Chinese herbs on the cell factors（IL-2,IL-6 and TNF） of the female guinea pig genital herpes virus modelled.Methods： The level of the cell factors was detected after infection on the 12th day.The test was divided into six groups： model groups treatmented by capsule Sihuanghu,blank control group and positive drug acyclovir（ACV） controlled.Results： Capsule Sihuanghu has the functions of improving IL-2.After virus infection,IL-6 levels in guinea pigs were lower,and ACV group and Capsule Sihuanghu high-dosed group fell the most.There are significant differences（P0.05;P0.01）.The levels of TNF in each dose group and positive drug acyclovir were increased,compared with model group and normal control group.But there are no significant differences（P0.05）.Conclusion： Capsule Sihuanghu containing Chinese herbs have certain regulations for IL-2,IL-6 and TNF in the female guinea pig genital herpes virus modeled.
出处
《江西中医学院学报》
2013年第3期75-77,共3页
Journal of Jiangxi College of Traditional Chinese Medicine
关键词
四黄虎胶囊
生殖器疱疹
豚鼠
细胞因子
Capsule of Sihuanghu
Genital Herpes
Female Guinea Pig
Cytokines
