摘要
目的探讨唑来膦酸对去势后的非转移性前列腺癌(PCA)骨密度(BMD)的影响观察及护理方法。方法将144例行去势治疗非转移性PCA患者分为两组各72例,护理干预后每日给予口服钙剂和维生素D治疗,同时给予患者唑来膦酸和生理盐水进行治疗,并给予患者心理护理、用药护理、饮食和行为护理等。观察患者BMD变化、生活质量的改善程度。结果护理干预后Ca、25-(OH)D及BMD均较护理干预前显著提高,且两组护理干预后比较差异有统计学意义(P<0.05)。护理干预后患者抑郁、焦虑自评分均比护理干预前显著提高(P<0.05)。护理干预后患者恐惧、自卑、担心影响夫妻关系的发生率显著低于护理干预前,差异有统计学意义(P<0.05)。护理干预后Karnofsky评分较护理干预前明显升高,差异有统计学意义(P<0.05)。护理干预后患者的依从性和满意度分别为97.2%和80.6%,显著高于护理干预前的91.7%和72.2%,差异均有统计学意义(P<0.05)。结论唑来膦酸在治疗去势后的非转移性PCA的同时配合精心护理,可有效提高BMD和改善患者的生活质量,值得在临床推广使用。
Objective To investigate the effect of zoledronic acid on ovariectomized non-metastatic prostate cancer （PCA） bone mineral density （BMD） to observe the effect and nursing methods. Methods A total of 144 patients with non metastatic castration in the treatment of PCA patients were divided into two groups, each group 72 cases, Nursing intervention before patients after castration was given daily oral calcium and vitamin D treatment, After nursing inter- vention patients received zoledronic acid and saline treatment, and patients were given psychological nursing, medica- tion nursing, diet and behaviour nursing care. The degree of improvement observed in patients with BMD change, quality of life. Results In group Ca, 25- intervention （OH） D and BMD were after nursing intervention improved signif- icantly, and the two groups after treatment, there were significant differences （P 〈 0.05）. After nursing intervention patients with depression and anxiety scores increased significantly than nursing intervention before （P 〈 0.05 ）. After nursing intervention patients fear, inferiority, worry about the occurrence rate of the relationship between husband and wife were significantly lower than nursing intervention before, the difference was statistically significant （P 〈 0.05）. After nursing intervention Karnofsky score increased obviously than nursing intervention before, the difference was sta- tistically significant （P 〈 0.05）. After nursing intervention patient compliance and satisfaction were 97.2% and 80.6%, significantly higher than those nursing intervention before 91.7% and 72.2%, the differences were statistically signifi- cant （P 〈 0.05）. Conclusion Zoledronic and phosphonic acid in non treatment of metastatic PCA after castration with careful nursing, can effectively improve the BMD and improve the quality of life of patients, and it is worthy of clinical application.
出处
《中国现代医生》
2013年第24期106-108,共3页
China Modern Doctor
基金
浙江省绍兴市科技计划项目(2009A33027)
关键词
前列腺肿瘤
卵巢切除术
唑来膦酸
骨密度
Prostate tmour
Oophoreetomy
Zoledronic acid
Bone mineral density
