摘要
目的探讨血清肿瘤标记物联合检测诊断胃癌的临床价值。方法选取65例经临床诊断为胃癌患者分入胃癌组,另选60例良性胃病患者分入良性胃病组,分别检测两组患者的癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原50(CA50)及糖类抗原19-9(CA19-9)血清肿瘤标记物水平,并对其单独及联合阳性检测率、灵敏度及特异度进行分析。结果两组患者的血清肿瘤标记物差异均具有统计学意义(P<0.05);胃癌组CEA、CA125、CA50及CA19-9阳性检测率分别为52.3%、32.3%、53.9%和38.5%,良性胃病组为18.3%、15.0%、11.7%和16.7%,差异有统计学意义(P<0.05);灵敏度依次为50.8%、46.2%、49.2%和61.5%,显著低于联合检测灵敏度84.6%(P<0.05);特异度依次为95.4%、92.3%、86.2%和95.4%,与联合检测特异度87.7%相比差异无统计学意义(P>0.05)。结论血清肿瘤标记物联合检测诊断胃癌具有重要的临床价值,有利于提高胃癌临床诊断的灵敏度。
Objective To explore clinical value of combined detection of serum tumor markers in gastric cancer diagnosis.Methods 65 patients clinically diagnosed as gastric cancer were selected as gastric cancer group,and 60 patients suffered from benign gastric disease as benign gastric disease group.The levels of four serum tumor markers of serum CEA,CA125,of CA50 and of CA19-9 were determined,and respcetive and combined detection positive rates,sensitivities and specificities were compared.Results There was a significant difference among the levesl of four serum tumor markers between the two groups（P0.05）.The positive detection rates of CEA,CA125,of CA50 and CA19-9 were 52.3%,32.3 %,53.9% and 38.5% in the gastric cancer group,and 18.3%,15.0%,11.7% and 16.7% in the benign gastric disease group,as were statistically differenet（P0.05）.Accordingly,sensitivities were 50.8%,46.2%,49.2% and 61.5%,significantly lower than that of combined detection（P0.05）.specificities in turn were 95.4%、92.3%、86.2% and 95.4%,which were not statistically different with 87.7% of combined detection（P0.05）.Conclusions Combined detection of serum tumor markers had an important clinical value and helped improving the sensitivities in the clinical diagnosis of gastric cancer.
出处
《中国肿瘤临床与康复》
2013年第7期702-704,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
