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新型N-取代四氢噻吩并[3,2-c]吡啶类衍生物的合成及其抗血小板聚集活性

Synthesis and Anti-platelet Aggregation Activities of Novel N-substituted-tetrahydrothienopyridine Derivatives
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摘要 以4,5,6,7-四氢噻吩并[3,2-c]吡啶为起始原料,设计并合成了一系列新型的含哌嗪结构的噻吩并吡啶类化合物(3a~3p),其结构经1H NMR,13C NMR,IR和ESI-HR-MS表征。大鼠体内抗血小板聚集活性研究表明,3a~3p均具有一定的抗血小板聚集作用,其中3a,3c,3i和3j的抑制率分别为66.8%,69.5%,70.4%和65.2%。 A series of novel piperazine-bearing thienopyridine derivatives(3a~3p) were designed and synthesized from 4,5,6,7-tetrahydrothienopyridine.The structures were characterized by 1H NMR,13C NMR,IR and ESI-HR-MS.In vivo anti-platelet aggregation tests in rats showed that 3a~3p exhibited certain anti-platelet aggregation activities.The inhibitions of 3a,3c,3i and 3j were 66.8%,69.5%,70.4% and 65.2%,respectively.
出处 《合成化学》 CAS CSCD 北大核心 2013年第4期387-392,共6页 Chinese Journal of Synthetic Chemistry
基金 国家科技重大专项"重大新药创制"课题资助项目(2013ZX09102014)
关键词 噻吩并吡啶 哌嗪 合成 抗血小板聚集活性 thienopyridines piperazine synthesis anti-platelet aggregation activity
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