摘要
目的:探讨艾司西酞普兰合并雌激素治疗女性更年期(综合征)抑郁症的疗效。方法:对64例女性更年期(综合征)抑郁症患者分别采用艾司西酞普兰合并雌激素尼尔雌醇(戊酸雌二醇)治疗组(33例,A组)和单用雌激素尼尔雌醇(戊酸雌二醇)治疗组(31例,B组),治疗前及治疗4周末用症状自评量表(SCL-90)、Zung氏焦虑自评量表(SAS)及Zung氏抑郁自评量表(SDS)评定疗效。结果:经4周治疗A组SCL-90评分降低值显著高于B组,两组有效率分别为84.38%和41.94%,有显著性差异(x2=12.23,P<0.01);治疗后艾司西酞普兰合并雌激素尼尔雌醇(戊酸雌二醇)治疗组的SAS、SDS评分明显低于单用雌激素尼尔雌醇(戊酸雌二醇)治疗组(P<0.05)。结论:艾司酞普兰合并雌激素尼尔雌醇对女性更年期(综合征)抑郁症有明显治疗作用,特别是能改善女性更年期患者的躯体化、抑郁、焦虑、恐怖症状,具有明显改善临床症状的功效。
Objective： To explore effects of escitalopram combined with estrogen in treatment of female climacteric（syndrome） depression.Methods： Sixty four female patients who suffered from climacteric syndrome were divided into escitalopram combined with estrogen（Nylestriol） therapy group（33 cases,group A） and single estrogen（Nylestriol） therapy group（31 cases,group B）.Then the therapeutic effects were evaluated by self rating scale（SCL-90）,Zung’s anxiety self-assessment scale（SAS） and Zung’s depression self rating scale（SDS） before and 4 weeks after the treatment.Results： 4 weeks after the treatment,the SCL-90 reduced score of group A were significantly lower than that of group B.The effective rates of A and B groups were 84.38% and 41.94%,and the difference was significant（x2 = 12.23,P ＆lt; 0.01）.Moreover,after the treatment,the SAS and SDS scores of group A were also significantly lower than those of group B（P ＆lt; 0.05）.Conclusions： Escitalopram combined with estrogen（Nylestriol） in the treatment of climacteric syndrome has an obvious therapeutic effect,and can especially improve the symptoms like somatization,depression,anxiety and phobia.In a word,it has a great effect on improvement of clinical symptoms.
出处
《中国民康医学》
2013年第15期9-12,共4页
Medical Journal of Chinese People’s Health
