摘要
目的 研究口服思密达对重度失血性休克预后的影响。方法 经股动脉放血制作兔失血性休克模型 ,分为休克组、思密达组 (休克前经胃管注入思密达 ) ,观察休克前后血浆内毒素、肿瘤坏死因子α(TNFα)、白介素 6 (IL 6 )、一氧化氮 (NO)水平的动态变化及 2 4、48小时的存活率。结果 休克组休克后血浆TNFα、IL 6、NO水平明显高于休克前 (P <0 0 1) ;与休克组比较 ,思密达组动物休克后血浆上述物质水平时显降低 ,动物存活率显著提高 (P <0 0 1)。结论 口饲思密达能减轻休克后的内毒素血症 ,减少TNFα、IL 6及NO的生成 ,有助于重度休克的纠正。
Objective To evaluate the effects of smecta in prolonged hemorrhagic shock.Methods The modified Wigger's method was used to induce hemorrhagic shock in anesthetized rabbits.Twenty-nine rabbits were randomly divided into hemorrhagic shock group(n=14),smecta group(n=15),with smecta solution being administered via a gavage tube before shock.The plasma levels of endotoxin,tumor necrosis factor α(TNFα),interleukin-6(IL-6) and nitric oxide(NO) were detected at pre-shock and post-shock,immediately after resuscitation and 2h after resuscitation.Blood culture was done at pre-shock,immediately after resuscitation,2h after resuscitation.The survival rates of 24h and 48h were observed.Results The plasma levels of endotoxin,TNFα,IL-6 and NO markedly increased after shock,and were maintained at high level in shock group (P<001).Compared with those in shock group,the plasma levels of endotoxin,TNFα,IL-6 and NO,positive incidence of blood culture decreased obviously,and survival rates of 24h and 48h increased significantly in smecta group (P<001).Conclusions Oral smecta can not only reduce the endotoxemia during shock,but also decrease the productions of cytokines and NO to improve the outcome of shock.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2000年第9期549-551,共3页
Chinese Journal of Anesthesiology
关键词
重度失血性休克
思密达
临床应用
预后
实验研究
Shock,hemorrhagic
Endotoxin
Tumor necrosis factor
Interleukin-6
Nitric oxide
Smecta
