摘要
目的 观察肾移植术后早期不同剂量霉酚酸酯 (MMF)与环孢素A(CsA)和泼尼松(Pred)联用预防急性排斥反应的效果及安全性。方法 将 6 4例肾移植患者分为 3组 ,分别给予MMF 2 .0 g/d(A组 )、1.5 g/d(B组 )及Aza 5 0～ 10 0mg/d(C组 ) ,每组均联用CsA及Pred(剂量相同 )。观察肾移植术后 6个月内急性排斥反应的发生率、移植肾功能及药物的副作用。结果 A、B、C组急性排斥反应的发生率分别为 11.1%、0及 2 7.5 % ;A、B组消化道的副作用多见 ,尤以A组为高 ,其它副作用 3个组的差异无显著性 ;移植肾功能延迟恢复的发生率 ,A、B两组明显高于C组。结论 不同诱导剂量的MMF与CsA和Pred短期联用 ,可有效预防术后早期急性排斥反应的发生 ;MMF除胃肠道的副作用较多外 ,其它副作用未见增多。
Objectives To investigate the efficiency and safety of combined use of different doses of Cellcept (MMF) with CsA and Pred at the early stage after renal transplantation for preventing and treating the acute renal allograft rejection. Methods Sixty-four cadaveric renal transplant recipients were randomly divided into 3 groups, receiving MMF 2.0 *!g/d, CsA and Pred (group A), MMF 1.5 *!g/d, CsA and Pred (group B) and Aza 50 to 100*!mg/d, CsA and Pred (group C) respectively. The incidence of the acute renal allograft rejection, the function of the renal graft and the different adverse effects in the recipients at the first 6 months after renal transplantation were observed. Results The incidence of the acute rejection was 11.11 *!%,0, 27.5 *!% in the groups A, B and C respectively. The frequency of diarrhea was the highest in the group A, and other side events were similar among the three groups. Conclusions Combined use of different doses of MMF with CsA and Pred could effectively prevent the occurrence of acute rejection at the early stage after transplantation. Except for the side events of gastrointestine, other MMF-induced side effects was not increased.
出处
《中华器官移植杂志》
CAS
CSCD
2000年第5期294-295,共2页
Chinese Journal of Organ Transplantation
关键词
肾移植
免疫抑制剂
移植物排斥
霉酚酸酯
Kidney transplantation
Immunosuppressive agents
Graft rejection
Treatment outcome
