摘要
以羟丙基-β-环糊精(HP-β-CD)为主体,十八胺(ODA)为客体,采用研磨法制备了具有超分子结构的ODA/HP-β-CD包合物。考察了研磨时间、主客体物质的量比及包合温度对包合率的影响,确定了包合物的最佳制备工艺:研磨时间15 min,主客体物质的量比2∶1,热处理温度75℃。1H-NMR和XRD衍射结果表明,ODA成功包合入HP-β-CD空腔中。通过相溶解度法研究了HP-β-CD在水中对ODA的增溶作用,结果表明HP-β-CD在水中对ODA增溶效果显著;经计算确定其包合常数为7877.69 L/mol,形成的包合物结构稳定。
An inclusion complex with octadecylamine （ODA） as guest and hydroxylpropyl-β--cyclodextrin （HP-β- CD） as host has been prepared by a grinding method. The influence of varying the grinding time, the molar ratio of host：guest and the temperature on the inclusion ratio was investigated. The optimum preparation conditions were as follows ： a molar ratio of host： guest of 2： 1, a grinding time of 20min, and a heating temperature of 75℃.1H-NMR spectroscopy and XRD confirmed that the ODA was successfully embedded in the cavity of HP-β-CD. The phase solubility method was used to study the influence of HP-β--CD on the solubility of ODA in water. It was found that HP-β--CD significantly increased the solubility of ODA in water. The inclusion constant was 7877.69 L/mol, which indicates that the inclusion complex was relatively stable.
出处
《北京化工大学学报（自然科学版）》
CAS
CSCD
北大核心
2013年第4期57-62,共6页
Journal of Beijing University of Chemical Technology(Natural Science Edition)
基金
国家"863"计划(2009AA032802/2009AA032803)
关键词
十八胺
羟丙基-Β-环糊精
超分子结构
包合物
octadecylamine
hydroxylpropyl-β-cyclodextrin
supramolecular
inclusion complex
