摘要
目的探讨补肾调周法对促排卵周期宫内人工授精(IUI)患者的临床疗效及机制。方法将60例接受IUI助孕并符合小卵泡排卵诊断的不孕症患者,统一选用氯米芬促排卵方案,随机分为对照组(氯米芬组)34例,治疗组(补肾调周系列方联合氯米芬组)26例。观察2组患者HCG注射日子宫内膜厚度及形态的变化及妊娠率。结果治疗后治疗组较对照组HCG注射日子宫内膜厚度明显增加(P<0.05);治疗组A型内膜占53.85%,B型占38.46%,而对照组分别为23.53%和29.41%,2组比较,差异有统计学意义(P<0.05);治疗组临床妊娠率为34.61%,周期妊娠率为19.56%,对照组分别为11.76%和6.06%,2组差异有统计学意义(P<0.05)。结论补肾调周法配合氯米芬,可明显提高IUI患者临床妊娠率,其机制可能与其增加子宫内膜厚度、改变子宫内膜形态,从而影响子宫内膜容受性有关。
Objective To explore the clinical efficacy and the mechanism of kidney-reinforcing and menstrual cycle-regulating（BSTZ） therapy in patients with ovulation induction cycle undergoing intrauterine insemination（IUI）.Methods Sixty infertile women undergoing IUI according with the small follicular ovulation criteria were randomly divided into two groups given the same clomiphene ovulation induction scheme,a control group（n=34） treated with clomiphene alone and a treatment group（n=26） with BSTZ prescriptions and clomiphene.The thickness and types of endometrium on the day of HCG injection and pregnancy rate were observed in both groups.Results After treatment,the treatment group obviously promoted the growth of endometrium on the day of HCG injection when compared with the control group（P 0.05）;type A endometrium accounted for 53.85%,B was 38.46% in the treatment group,while in the control group,type A and B endometrium accounted for 23.53% and 29.41% respectively,with significant difference（P 0.05）;the clinical pregnancy rate was 34.61% and the cycle pregnancy rate was 19.56% in the treatment group,while 11.76% and 6.06% respectively in the control group,with significant difference（P 0.05）.Conclusion Kidney-reinforcing and menstrual cycle-regulating therapy combined with clomiphene could significantly improve the clinical pregnancy rate of patients undergoing IUI,and its possible mechanism might be related with enhancing endometrial receptivity by increasing endometrial thickness and changing the type of endometrium.
出处
《北京中医药》
2013年第6期431-433,共3页
Beijing Journal of Traditional Chinese Medicine
关键词
补肾调周法
宫内人工授精
妊娠率
子宫内膜容受性
kidney-reinforcing and menstrual cycle-regulating therapy
intrauterine Insemination
clinical pregnancy rate
endometrial receptivity
