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矢车菊-3-葡萄糖的抗癌效应研究进展 被引量:7

Research Progress in Anticancer Effect of Cyanidin-3-glucoside
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摘要 花色苷是一类天然的黄酮类化合物,广泛分布在人们日常饮食的水果蔬菜中。大量的流行病学与动物实验研究表明花色苷具有癌症化学预防作用。本文总结了在大多数浆果及相关产品中分布最普遍、含量高的花色苷-矢车菊-3-葡萄糖苷的抗癌效应,这种效应主要通过抗氧化、激活Ⅱ相解毒酶、抗细胞增殖、诱导细胞凋亡、抗炎效应、抗血管生成、抗细胞侵入、诱导细胞分化等机制来发挥,本文概述了矢车菊-3-葡萄糖苷的癌症预防效应。 Anthocyanins are a group of naturally occurring flavonoid compounds,which is widely available in fruits and vegetables in human diets.A lot of epidemiological and animal experiments have demonstrated that anthocyanins may contribute to cancer chemoprevention.In this article,we summarize the anti-cancer effects and the mechanisms of anthocyanins and cyanidin-3-glucoside(C3G) in berries and related food products on several key steps: antioxidant effects,enzyme activation,anti-cell proliferation,apoptosis induction,anti-inflammation,anti-angiogenesis,anti-invasiveness,and differentiation induction.This review provides a molecular view of cyanidin-3-glucoside contributing to cancer chemoprevention.
出处 《食品科学》 EI CAS CSCD 北大核心 2013年第13期329-333,共5页 Food Science
基金 国家公益性行业(农业)科研专项(201103037) 北京市属高等学校人才强教深化计划资助项目 北京市职业院校职教名师资助项目
关键词 花色苷 矢车菊-3-葡萄糖苷 抗癌效应 anthocyanins cyanidin-3-glucoside anti-cancer effect
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参考文献34

  • 1KONG Jinming,CHIA L S,GOH N K,et al.Analysis and biologicalactivities of anthocyanins[J].Phytochemistry,2003,64(5):923-933.
  • 2PRIOR R L,WU Xianli.Anthocyanins:structural characteristics thatresult in unique metabolic patterns and biological activities[Jj.FreeRadical Research,2006,40(10):1014-1028.
  • 3WU Xianli,PRIOR R L.Systematic identification and characterizationof anthocyanins by HPLC-ESI-MS/MS in common foods in the UnitedStates:fruits and berries[J].Journal of Agricutral and Food Chemistry,2005,53(7):2589-2599.
  • 4WELCH C R,WU Qingli,SIMON J E.Recent advances inanthocyanin analysis and characterization [J].Current AnalyticChemistry,2008,4(2):75-101.
  • 5World Health Organization.Globocan 2008(IARC)section of cancerinformation[R].Inemational Agency for Research on Cancer:WHO,2008.
  • 6SURH Y J.Cancer chemoprevention with dietary phytochemicals [J],Nature Review Cancer,2003,3(10):768-780.
  • 7NISHINO H,MURAKOSHI M,MOU Xiaoyang,et al.Cancerprevention by phytochemicals[J].Oncology,2005,69(1):38-40.
  • 8SUN Chongde,ZHENG Yixiong,CHEN Qingjun,et al.Purificationand anti-tumor activity of cyanidin-3-O-glucoside from Chinesebayberry fruit[J].Food Chemistry,2012,131(4):1287-1294.
  • 9SHIH P H,YEH C T,YEN G C.Effects of anthocyanidin on theinhibition of proliferation and induction of apoptosis in human gastricadenocarcinoma cells[J].Food and Chemical Toxicology,2005,43(10):1557-1566.
  • 10REDDY M K,ALEXANDER-LINDO R L,NAIR M G.Relativeinhibition of lipid peroxidation,cyclooxygenase enzymes,andhuman tumor cell proliferation by natural food colors [J].Journal ofAgricutural and Food Chemistry,2005,53(23):9268-9273.

二级参考文献16

  • 1Lillemoe K D. Currentmanagement of pancreatic carcinoma [ J ]. Ann Surg, 1995,221:133-148.
  • 2Jemal A, Thomas A, Murray T, et al. Cancer statistics 2002 [ J]. CA Cancer J Clin, 2002 ;52:23 - 47.
  • 3Tada M, Arizumi M, Nakai Y, et al. Efficacy of gemcitabine for lo- cally advanced pancreatic cancer: comparison with 5 - fuorouracil - based chemoradiotherapy [ J ]. Chemotherapy, 2008,54 (4) : 302 - 308.
  • 4Hakimuddin F, Paliyath G, Meckling K. Selective cytotoxicity of a red grape wine flavonoid fraction against MCF -7 cells [ J]. Breast Cancer Res Treat, 2004,85( 1 ) :65 -79.
  • 5Galvano F, La Fauci L, Lazzarino G, et al. Cyanidins: metabolism and biological properties [J]. J Nutr Biochem, 2004,15( 1 ) :2 -11.
  • 6Lea MA, Ibeh C, desBordes C, et al. Inhibition of growth and induc- tion of differentiation of colon cancer cells by peach and plum phenolic compounds [ J ]. Anticancer Res, 2008,28 ( 4 B ) : 2067 - 2076.
  • 7Zhang Y, Seeram NP, Lee R, et al. Isolation and identification of strawberry phenolics with antioxidant and human cancer cell antiprolif- erative properties [ J ~. J Agric Food Chem, 2008,56 ( 3 ) :670 - 675.
  • 8Fimognari C, Berti F, Nusse M, et al. In vitro antitumor activity of cyanidin - 3 - O - beta - glucopyranoside [ J ]. Chemotherapy, 2005, 51 (6) :332 - 335.
  • 9Chen PN, Chu SC, Chiou HL, et al. Cyanidin- 3 -glucoside and peonidin 3 - glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo [J]. Nutr Cancer, 2005, 53(2) :232 -243.
  • 10Chen PN, Chu SC, Chiou HL, et al. Mulberry anthocyanins, cyani- din 3 - rutinoside and cyanidin 3 - gtucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line [ J ]. Cancer Lett, 2006,235 (2) :248 - 259.

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