摘要
目的探讨结核病初治方案中异烟肼的用药剂量对肺结核病初治患者疗效及预后的影响。方法采用随机配对方法,将90例既往无肝病史的肺结核痰菌(+)初治患者分为治疗组和对照组。对照组按标准短程化疗方案,治疗组异烟肼的用药剂量加量为0.5 g/(次.d),余同标准短程化疗方案。结果治疗组痰菌涂片和培养转阴率均为88.9%;对照组则分别为71.1%、68.9%,两组存在显著性差异(P<0.05);肝功能损害率和停药率治疗组和对照组分别为28.9%、11.1%与24.4%、8.9%,差异无显著性(P>0.05)。结论标准短程化疗方案中异烟肼的血药浓度常低于正常治疗浓度,适当提高临床中异烟肼的用量,可提高结核病初治患者的痰菌阴转率和治愈率,减少结核病的复发及耐药结核的产生,对临床具有重要的意义。
Objective To explore the dosage of isoniazid in tuberculosis treatment programme on efficacy and prognosis of patients with pulmonary tuberculosis.Methods By using random pairing method,90 patients without history of liver disease with positive TB（＋） sputa for initial treatment were divided into trial group（group A） and control group（group B）.Patients in control group were treated with standard short-course chemotherapy,and patients in trial group were treated by standard short-course chemotherapy in addition with isoniazid at dosage of 0.5 g / time / day.Results The negative inversion rates of sputum smear and culture in trial group were both 88.9%;and those in control group were 71.1% and 68.9%,the difference between these two groups was significant（P 0.05）;and the rate of impairment in liver function and withdrawal rate were 28.9%,11.1% and 24.4%,8.9% in two groups respectively.Conclusion The blood drug concentration of isoniazid in standard short-course chemotherapy regimen is often lower than normal concentration,hence appropriate increase in dosage of isoniazid can raise the negative inversion rate in sputum and cure rate in patients with tuberculosis,and reduce the relapse and drug resistance of tuberculosis,and it has important significance in clinical practice.
出处
《临床和实验医学杂志》
2013年第14期1111-1112,共2页
Journal of Clinical and Experimental Medicine
关键词
结核病
初治
异烟肼
剂量
疗效
Tuberculosis
The initial treatment
Isoniazid
Dosage
Effect
