摘要
目的:探讨扁平苔藓皮损中细胞信号传导和转录激活因子(STAT3)、血管内皮生长因子(VEGF)、细胞周期素D1(CyclinD1)的表达及其意义。方法:采用免疫组化法检测23例扁平苔藓皮损中STAT3、VEGF、CyclinD1的表达,与12例正常皮肤、黏膜组织作对照,并分析其相关性。结果:STAT3、VEGF、CyclinD1在扁平苔藓皮损中阳性表达率分别为60.87%(14/23)、69.57%(16/23)和56.52%(13/23),在正常皮肤、黏膜组织中阳性表达率分别为8.33%(1/12)、16.67%(2/12)和8.33%(1/12),差异均有统计学意义(P<0.05)。扁平苔藓中STAT3与VEGF的表达,STAT3与CyclinD1的表达,VEGF与CyclinD1的表达均呈正相关(r=0.631,0.734,0.564;P=0.001,0.000,0.005)。结论:STAT3、VEGF、CyclinD1在扁平苔藓的发生、发展中可能起一定作用,三者之间可能相互协调。
AIM： To investigate the expres- sion of signal transducers and activators of tran- scription 3 （ STAT3 ）, vascular endothelial growth factor（VEGF）, CyclinD1 and their cor- relation in the lesions of lichen planus. METH- ODS： The expression levels of STAT3, VEGF and CyclinD1 in the 23 cases of lesions of lichen planus were detected by the immunohistochemis- try,and 12 cases of normal human tissues were also detected as control group. The expression and their relationship with pathological factors were analyzed. RESULTS. The expression rates of STAT3,VEGF and CyclinD1 in lichen planus were 60. 87% （ 14/23 ） 56.52% （13/23）, the 69.57% （ 16/23 ） and expression ratesSTAT3, VEGF and CyclinD1 in the normal group were 8. 33% （1/12）, 16.67% （2/12） and 8.33%（1/12）. Compared with the control, the difference were significant （P〈0.05）. Positive correlation between expression of STAT3 and VEGF, STAT3 and CyclinD1, VEGF and Cy- clinD1（r=0.631, 0.734, 0.564; P=0.001, 0. 000, 0. 005 ） were found. CONCLUSION： STAT3,VEGF and CyclinD1 may play a role in the development in the incidence of lichen pla- nus,coordination between them may play a role.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2013年第8期874-878,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
