摘要
目的:探讨丙泊酚与七氟烷对骨科老年手术患者术后认知功能的影响。方法:将行骨科手术的120例老年患者随机分为丙泊酚组和七氟烷组各60例。麻醉诱导后,丙泊酚组患者予以丙泊酚靶控输注泵泵注丙泊酚1～3μg/ml维持麻醉,七氟烷组予以1%～3%七氟烷吸入维持麻醉。对2组患者手术前后的血清S100β水平和认知功能进行比较。结果:丙泊酚组患者术后1、3和6 h认知功能得分均较术前下降(P<0.01),术后1 d认知功能得分与术前相比,差异无统计学意义(P>0.05);而术后3 d认知功能得分则高于术前(P<0.01)。七氟烷组患者术后1、3、6 h认知功能得分均较术前下降(P<0.01),术后1、3 d认知功能得分与术前相比,差异均无统计学意义(P>0.05)。七氟烷组患者术后1 h、3 h、6 h、1 d和3 d认知功能得分均低于丙泊酚组(P<0.01)。术后2组患者血清S100β水平均较术前显著升高(P<0.01),而且七氟烷组患者显著高于丙泊酚组(P<0.01)。结论:丙泊酚与七氟烷均可影响患者的认知功能,其中七氟烷对认知的影响最为严重。
Objective： To explore the effects of propofol and sevoflurane anesthesia on postoperatively cognitive function of aged patients in orthopedics.Methods： One hundred and twenty aged patients undergone orthopedic surgery were randomly divided into propofol and sevoflurane group（60 cases,each group）.The propofol and sevoflurane group were anesthetized by injection 1 to 3 μg / ml of propofol and inhalation 1% to 3% of sevoflurane after anesthesia induction,respectively.The serum levels of S100 β and cognitive function in two groups were compared before and after operation.Results： Compared with preoperation,the scores of cognitive function in the propofol group decreased at 1,3 and 6 hours after operation（P 0.01）,the difference of cognitive function score beteween postoperative 1 hour and before operation has no statistic significance（P 0.05）,but its score at postoperative 6 days was higher（P 0.01）.Compared with preoperation,the scores of cognitive function in the sevoflurane group decreased at 1,3,6,24 and 72 hours after operation（P 0.01）,the differences of cognitive function score beteween postoperative 1 and 72 hours and before operation have no statistic significance（P 0.05）.The scores of cognitive function in the sevoflurane group were lower than those in propofol group at 1,3,6,24 and 72 hours after operation（P 0.01）.Compared with preopration,the postoperative serum levels of S100 β protein in two groups were significant higher（P 0.01）,the level of S100 β in the sevoflurane group was significantly higher than those in propofol group（P 0.01）.Conclusions： Both propofol and sevoflurane affect the patient＇s cognitive function,the effect of sevoflurane is the most.
出处
《蚌埠医学院学报》
CAS
2013年第8期982-984,共3页
Journal of Bengbu Medical College
关键词
麻醉
丙泊酚
七氟烷
认知功能
骨科
propofol
sevoflurane
cognitive function
orthopedics
