摘要
目的研究低聚半乳糖对小鼠免疫功能的影响。方法昆明种小鼠随机分为低、中、高3个剂量组和1个阴性对照组,剂量组动物分别灌胃给予83.3、833和2500mg/kg体重的低聚半乳糖,阴性对照组给予去离子水,连续灌胃30d后,对小鼠进行细胞免疫指标、体液免疫指标、巨噬细胞吞噬功能及NK细胞活性测定。结果中、高剂量组小鼠足跖肿胀度值和血清半数溶血值(HC50)明显高于阴性对照组(P<0.01),低、中剂量组小鼠碳廓清指数明显高于阴性对照组(P<0.01)。结论在该试验条件下,低聚半乳糖对小鼠具有免疫增强作用。
Objective To study the effects of Galacto-oligosaccharides on the immune function in mice.Methods Mice were randomly divided into control group,low dose group,middle dose group and high dose group.The animals in exposure groups were given intragastrically with Galacto-oligosaccharides by the doses of 83.3、833 and 2 500 mg/kg body weight respectively.The control group was given deionized water.The data of cellular immunity,humoral immunity,macrophage phagorytosis function and the activities of NK cells were examined and collected after 30 days.Results The toe swelling value and the content of serum hemolysis（HC50）of middle and high dose groups were significant higher than that of control group（P0.01）.The index of macrophages for carbon clearance of low and middle dose groups were significant higher than that of control group（P0.01）.Conclusion The results indicated that Galacto-oligosaccharides could enhance the immune function in mice.
出处
《首都公共卫生》
2013年第4期163-165,共3页
Capital Journal of Public Health
关键词
低聚半乳糖
免疫功能
小鼠
Galacto-oligosaccharides
Immune function
Mice
