摘要
目的探讨Roux-en-Y胃空肠短路术在糖尿病患者中的应用效果。方法采用Roux-en-Y胃空肠短路术治疗23例2型糖尿病(T2DM)患者,观察其治疗效果。结果术后1个月23例患者糖耐量,各时间点的血糖值均显著低于手术前(P<0.01);术后1、6个月时空腹血糖(FPG)、餐后2 h血糖(2hPG)、糖化血红蛋白(HbA lc)、胰岛素抵抗指数(HOMA-IR)均显著低于术前(P<0.01),术后1个月与术后6个月比较无统计学差异(P>0.05),但空腹胰岛素(Fins)手术前后未见明显变化(P>0.05);23例中治愈16例(69.6%),好转7例(30.4%);均未发生吻合口瘘、切口感染、出血、肺部感染等并发症。结论 Roux-en-Y胃空肠短路术在T2DM患者中的应用取得了较为理想的效果,术后血糖控制理想,且能长期维持,术后并发症较少,但该手术对于T2DM患者的确切疗效仍需大样本研究证实。
Objective To discuss the clinical effects of Roux-en-Y gastrointestinal bypass on patients with type 2 diabetes mellitus （T2DM）. Methods Twenty-three patients with T2DM were treated with Roux-en-Y gastrointestinal bypass operation, and then their clinical effects were observed. Results The values of oral glucose tolerance test （OGTF） at different time points 1 month af- ter the operation were significantly lower than that before （ P 〈 0.01 ）. Such parameters, as fasting plasma glucose （ FPG）, 2-hour postprandial plasma glucose （2hPG） , glycosylated hemoglobin Alo （HbAI~） and homeostasis model assessment of insulin resistance （HOMA-IR） 1 and 6 month（s） after operation were significantly lower than that before （ P 〈 0.01 ） ; there were no significant differences in the above parameters when compared between 1 and 6 month （ s ） after operation （ P 〉 0.05 ）. There was no sig- nificant difference in fasting insulin （FINS） after operation （ P 〉 0.05 ）. In the 23 patients, 16 （69.6%） were cured and 7 （ 30.4 % ） were improved. There were no anastomotic fistula, wound infection, bleeding, lung infection and other postoperative complications. Conclusion The application of Roux-en-Y gastrointestinal bypass to patients with T2DM can ideally control blood sugar with long- term maintenance and few complications. At the same time, further studies are needed to confirm its exact effect.
出处
《临床军医杂志》
CAS
2013年第8期808-809,815,共3页
Clinical Journal of Medical Officers
