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HLA-DQA1基因拷贝数目多态性与中国汉族人群类风湿关节炎易感性的研究 被引量：1

Research between the Polymorphisms of HLA-DQA1 Gene Copy Number and the Susceptibility to Rheumatoid Arthritis in Chinese Han Population
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摘要 目的:探讨中国汉族人群中HLA-DQAl基因拷贝数目多态性与类风湿关节炎发病风险的关系。方法:采用比较基因组杂交和AccuCopy检测技术,检测138例类风湿关节炎患者和191例正常对照者的HLA-DQAl基因拷贝数目。采用Logistic回归模型分析各基因型患者类风湿关节炎的发病风险。结果:HLA-DQAl基因拷贝数目增加的个体,类风湿关节炎发病风险显著升高(P=0.009)。结论:HLA-DQAl基因拷贝数目多态是RA的遗传易感因素,HLA-DQAl基因拷贝数目增加则是类风湿关节炎的危险因素。 Objective：To explore the association between the polymorphisms of HLA-DQA1 gene copy number and the onset risk of rheumatoid arthritis in Chinese Han population.Methods：The HLA-DQA1 gene copy numbers of 138 patients with rheumatoid arthritis and 191 controls were detected by comparative genomic hybridization （ CGH ） and AccuCopy assay.Logistic regression model was used to evaluate the impact of this polymorphism on the risk of pathogenesis of rheumatoid arthritis.Results：Carriers with larger number of HLA- DQA1 gene duplication had a significantly increasing risk of rheumatoid arthritis （ P = 0.009 ） .Conclusion：The polymorphism of HLA-DQA1 gene copy number was the predisposing factor of heredity and the increasing number of HLA-DQA1 gene duplication was a risk factor for rheumatoid arthritis.
作者 陈洁君 吉恒东 郭士成 王一 李媛 金力 王久存 宋新强
机构地区 中国生物技术发展中心 泰州市人民医院 复旦大学生命科学学院现代人类学教育部重点实验室 信阳师范学院生命科学学院
出处 《风湿病与关节炎》 2013年第8期5-8,共4页 Rheumatism and Arthritis
基金 上海市科委政府间国际合作项目(11410701800)
关键词 关节炎 类风湿 HLA—DQAl 拷贝数目多态性 易感性 中国汉族人 arthritis,rheumatoid HLA-DQA1 copy number polymorphisms susceptibility treatment Chinese Han population
分类号 R593.22 [医药卫生—内科学]
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参考文献20

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共引文献15

同被引文献22

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风湿病与关节炎
2013年 第8期

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