摘要
目的探讨奥沙利铂(L-ohp,)联合亚叶酸钙(CF)及5-氟尿嘧啶(5-Fu)(FOLFOX方案)治疗晚期胃癌患者的疗效及毒副反应。方法将本院2009年3月—2013年3月收治的48例晚期胃癌患者随机均分成2组,分别给予单纯手术治疗和手术联合FOLFOX6治疗,4周为一个疗程,连用3个疗程后评价2组的疗效及不良反应情况。结果 48例患者总有效率为35.4%,总控制率为77.1%。FOLFOX6组有效率优于单纯手术治疗组,差异有统计学意义(P<0.05)。结论 FOLFOX方案治疗晚期胃癌疗效肯定,副反应较轻,患者耐受性好,值得临床推广应用。
Objective To study the clinical efficacy of FOLFOX regimen, oxaliplatin（L- OHP） combined with fluorouracil（5-ru）and calcium folinate（CF） in the treatment of advanced gastric cancer. Methods Forty-eight patients with advanced gastric cancer admitted into our hospital from March 2009 to March 2013 were randomly divided into two groups, 24 patients in each group. The first group was treated with operation only, and the other was treated with FOLFOX6. Each group was repeated every 2 weeks. All patients received three cycles of chemotherapy at least. The efficacy was observed and the difference between two groups was compared. Results The total efficacy rate was 35.4 % and the total controllability was 77.1%. The FOLFOX6 group had a better effect than the counterpart group, the difference being statistical significant （P 〈 0.05）. Conclusion FOLFOX is a high response regimen for advanced gastric cancer and its toxicity is tolerable.
出处
《实用临床医药杂志》
CAS
2013年第15期129-131,共3页
Journal of Clinical Medicine in Practice
关键词
奥沙利铂
5-氟尿嘧啶
亚叶酸钙
晚期胃癌
联合化疗
oxaliplatin
5-fluorouracil
leueovorin
advanced gastric cancer
combined chemotherapy
