瑞芬太尼复合丙泊酚在无痛肠镜中的应用被引量：4

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摘要目的探讨瑞芬太尼复合丙泊酚在无痛肠镜中的应用效果。方法将自愿接受实施无痛纤维结肠镜检查的80例患者,随机均分为瑞芬太尼复合丙泊酚(R组)和丙泊酚(P组)。P组:丙泊酚1.5～2.5 mg/kg静注。R组:依次静注瑞芬太尼1.0μg/kg、丙泊酚1.0～2.0 mg/kg,至患者睫毛反射消失,呼叫不应时开始检查。观察2组患者在无痛肠镜检查中的麻醉效果。结果 2组患者均SPO2>95%,差异无统计学意义。P组镜检中各时点HR、MAP高于镜检前(T0)(P<0.05)。R组T1时HR、MAP低于T0(P<0.05)。T2～T4时R组HR慢于P组,P<0.05。P组麻醉起效时间、苏醒时间长于R组(P<0.05)。丙泊酚的用量P组大于R组(P<0.01)。体动反应P组高于R组。结论与单纯应用丙泊酚比较,瑞芬太尼复合丙泊酚用于结肠镜检查,术中体动少,丙泊酚用量小,血流动力学平稳,术后恢复快,并发症少,可安全有效的应用于临床。

作者闫梅英毛仁德

机构地区河南安钢职工总医院麻醉科

出处《河南外科学杂志》 2013年第4期116-117,共2页 Henan Journal of Surgery

关键词电子肠镜瑞芬太尼丙泊酚

分类号 R614 [医药卫生—麻醉学]

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参考文献2

1姜希,欧阳文.无痛性消化道内镜术[M].长沙:中南大学出版社,2002:1-3.
2汪芳俊,万勇,刘洋,涂发平.雷米芬太尼导致术后痛觉过敏的剂量依赖关系[J].临床麻醉学杂志,2009,25(11):937-939. 被引量：30

二级参考文献9

1Vinik HR, Kissin I. Rapid development of tolerance to analgesia during remifentanil infusion in humans. Anesth Analg, 1998, 86:1307-1311.
2Angst MS, Koppert W, Pahl I, et al. Short-term infusion of the mu opioid agonist remifentanil in humans causes hyperalgesia during withdrawal. Pain, 2003, 106: 49-57.
3Guignard B, Bossard AE, Coste C, et al. Acute opioid tolerance: intraoperative remifentanil increases postoperative pain and morphine requirement. Anesthesiology, 2000, 93: 409- 417.
4Trafton JA, Abbadie C, Marek K, et al. Postsynaptic signaling via the [mu]-opioid receptor: responses of dorsal horn neurons to exogenous opioids and noxious stimulation. J Neurosci, 2000, 20: 8578-8584.
5Borgland SL. Acute opioid receptor desensitization and tolerance: is there a link? Clin Exp Pharmacol Physiol, 2001, 28: 147-154.
6Gardell LR, Wang R, Burgess SE, et al. Sustained morphine exposure induces a spinal dynorphin-dependent enhancement of excitatory transmitter release from primary afferent fibers. J Neurosci, 2002, 22:6747-6755.
7Laulin JP, Maurette P, Corcuff JB, et al. The role of ketamine in preventing fentanyl-induced hyperalgesia and subsequent acute morphine tolerance. Anesth Analg, 2002, 94: 1263-1269.
8Joly V, Richebe P, Guignard B, et al. Remifentanil-indueed postoperative hyperalgesia and its prevention with small dose ketamine. Anesthesiology, 2005, 103: 147-155.
9王静捷,易杰,罗爱伦,黄宇光.术中输注不同剂量瑞芬太尼对子宫切除术后病人吗啡用量的影响[J].中华麻醉学杂志,2007,27(7):594-598. 被引量：4