摘要
目的:设计合成一系列苯乙烯基香豆素类化合物,并通过药理筛选寻找具有抗肿瘤活性的药物。方法:通过相转移Wittig反应得到目的物,利用几种药理模型进行体外抗肿瘤活性筛选。结果:合成了30个(I1～III6)新的苯乙烯基香豆素类化合物并确定其构型。结论:药理筛选结果表明,7个化合物(I2,I4,II2,II2c,III1a,III2a,III5a)对L1210,HL60,HCT8,KB和Bel7402细胞株有效,显示了一定的抗肿瘤活性。
AIM: A series of styrylcoumarin derivatives had been designed in order to find compounds of antitumor activities by screening in vitro . METHODS: Title compounds (I 1～III 6) were synthesized by phase transfer Wittig reaction and screened by several antitumor models in vitro . RESULTS: Thirty new compounds of 6 or 7 styrylcoumarin(I 1～III 6) were synthesized and their configurations were determined. Seven compounds(I 2,I 4,II 2,II 2c ,III 1a ,III 2a and III 5a ) showed different inhibitory effects on L 1210, HL 60, HCT 8, KB and Bel 7402 cell lines in vitro . CONCLUSION: Some 6 or 7 styrylcoumarin derivatives showed antitumor activities and is worth further study.
出处
《药学学报》
CAS
CSCD
北大核心
2000年第2期103-107,共5页
Acta Pharmaceutica Sinica
