摘要
含铜宫内节育器(intrauterine contraceptive device,IUD)作为我国已婚育龄妇女使用最广泛的避孕方法,其生物安全性、避孕的有效性和不良反应值得我们关注。实验室研究发现,相同形状的两种含铜IUD因含铜面积不同,其表现出来的细胞毒性也不同,含铜面积越大,细胞毒性越大。吲哚美辛的释放可以促进铜离子的释放,增加铜的生物毒性。临床研究发现,随着铜表面积的增加,带器妊娠率和宫外妊娠率也依次降低。同一类型和规格的IUD,铜表面积的增加对临床不良反应的发生率影响较小。目前的研究尚未发现含铜IUD对服务对象产生有临床意义的伤害。
The copper Intrauterine contraceptive device （IUD） is the most widely used contraceptive methods among the married women of childbearing age in China. Its biological safety, contraceptive efficacy and side effects was worthy of our attention. Laboratory studies have found that two of the same shape copper IUD, their cytotoxicity is not the same, due to the type of copper area. With the increase in surface area of copper, cytotoxicity is gradually increasing. The release of Indomethacin can promote the release of copper ions, to increase the biological toxicity of copper. Clinical studies have found that, with the increase in the surface area of copper IUD, the pregnancy rate with IUD and ectopic pregnancy rate is also gradually reduced. The same type and size of the IUD, the increase in the surface area of the copper is less impact on the incidence of clinical side effects. The current studies have not found the copper iud clinically significant damage on the service object.
出处
《中国计划生育和妇产科》
2013年第4期24-26,共3页
Chinese Journal of Family Planning & Gynecotokology
基金
国家"十一五"科技支撑计划课题(编号:2006BAI15B05)
关键词
宫内节育器
生物安全性
带器妊娠
不良反应
intrauterine contraceptive device
biological safety
pregnancy with IUD
side effect
