摘要
目的观察盆炎消灌肠液连续给药后对大鼠的毒性反应。方法盆炎消灌肠液分别按照50g.kg-1、25g.kg-1和12.5g.kg-1的剂量连续给药12周,停药2周,测量受试大鼠的体重,计算重要器官脏器系数,测定血液学及血液生化学指标,并作组织病理学检查。结果与空白对照组比较,高、中、低剂量盆炎消灌肠液对大鼠的体重增长、脏器系数、血液指标、血液生化学指标均无显著影响,病理学检查未见明显病变,停药后也未见延迟性毒性反应。结论盆炎消灌肠液长期用药对大鼠无明显毒性,按临床拟用剂量服用是安全的。
Objective To observe the long-term toxicity and severity occurred after administration of Penyanxiao enema in rats. Methods SD rats were randomly divided into 4 groups. Each group was given Penyanxiao enema at dose of 50g.kg-1,25g.kg-1 and 12.5g.kg-1 daily for up to 12 weeks, respectively. Blank control group was given same bulk of distilled water. After the withdrawal of the drug for 2 weeks the rats＂ body weight, food intake, hematology, blood biochemistry analysis and organ coefficients were measured, and the histopathological changes were also observed. Results The outer appearance and behavior, body weights, organ coefficients, the indexes of hemstology and biochemistry analysis in rats of drug taking groups showed no significant difference from those of control group. Pathological examination discovered no obvious pathological changes related to drug toxicity and no delayed toxicity reaction after drug withdrawal. Conclusion Penyanxiao enema had no obvious toxicity in rats for long-term administration.
出处
《中国药物警戒》
2013年第8期452-455,共4页
Chinese Journal of Pharmacovigilance
