摘要
目的探讨度洛西汀治疗抑郁症伴躯体疼痛障碍的临床效果。方法选取2009年5月～2012年3月我科收治的抑郁症伴躯体疼痛障碍患者83例。将其分为实验组和对照组,两组分别采用度洛西汀治疗(度洛西汀40 mg/d,7～14 d内逐渐增量至50～60 mg,稳定用药)和阿米替林治疗(阿米替林100 mg/d,7～14 d内逐渐增量至200～250 mg,稳定用药)。比较两组患者治疗效果。结果治疗42天后,两组HAMD,MOSPM评分较治疗前均明显下降(P均<0.05),实验组有效率明显高于对照治疗组(P<0.05),对照组中发生嗜睡、口干、头迷、便秘等不良反应均显著高于实验组(P<0.05)。结论度洛西汀与阿米替林相比,对抑郁症伴躯体疼痛障碍治疗疗效快、效果显著,具有较高的适用性,值得临床推广使用。
Objective： To study the efficacy of using Duloxetine on the treatment of pain and disorder with somimatic symptoms of depression.Methods： A total of 83 cases of patients with body pain disorder depressive symptoms were randomly divided into the study group（Duloxetine） and the control group（Amitriptyline）.HAMD MOSPM TESS HAMA was used and laboratory tests were used to evaluate the efficacy and safety for depression associated with body pain disorder,depression,anxiety and pain.Results： After 42 days treatment,the scales of HAMD MOSPM in the two groups significantly reduced（P0.05）.Compared with the control group,the study group had higher effective rate（P0.05）.The control group showed significantly more side effects（P0.05） in hypersomnia,thirst,dizzy and constipation,while the study group had slight symptom of digestive tract.Conclusion： Duloxetine can improve the depression with body pain.
出处
《泰山医学院学报》
CAS
2013年第2期116-118,共3页
Journal of Taishan Medical College
