摘要
目的研究重型颅脑损伤患者急诊手术后颅内感染相关因素,为制定临床预防对策提供参考。方法回顾性分析神经外科于2008年1月-2012年12月收治的重型颅脑损伤急诊手术后发生颅内感染的患者102例(感染组),并选择同期未发生感染的130例(非感染组),采用χ2检验、单因素及多因素非条件logistic回归分析,模型筛选采用Stepwise法,评价影响感染的相关因素。结果单因素分析显示,年龄≥50岁、术前GCS评分、手术次数、手术时间、术后白蛋白水平以及是否发生切口脑脊液漏是颅内感染的危险因素(P<0.05);而多因素分析进一步显示,其中是否发生切口脑脊液漏危险性最高(OR=5.768),其余依次为手术次数、低蛋白血症、手术时间、术前GCS评分及高龄(OR>1)。结论多种危险因素与重型颅脑损伤急诊手术后颅内感染关系密切,临床应针对性地采取预防对策,达到有效控制感染的目的。
OBJECTIVE To study the related factors for intracranial infections after the emergency surgery for craniocerebral injury so as to put forward prevention countermeasures.METHODS A total of 102cases of severe craniocerebral injury patients with intracranial infections who were treated in the neurosurgery department from Jan 2008to Dec 2012were chosen as the infection group,while during the same period 130cases of patients without intracranial infections were selected as the non-infection group,then the chi-square test,univariate analysis,and multivariate logistic regression analysis were carried out,and the model screening was performed by using Stepwise method,finally the related factors for the infections were observed.RESULTS The univariate analysis showed that the advanced age（more than 50years old）,preoperative GCS score,frequency of surgery,operation duration,postoperative albumin level,and incision cerebrospinal fluid leakage were the risk factors for intracranial infections（P0.05）;while the multivariate analysis indicated that the incision cerebrospinal fluid leakage was the highest risk factor（OR=5.768）,followed by the operation frequency,hypoalbuminemia,operation duration,preoperative GCS score,and the advanced age（ORare greater than 1）.CONCLUSIONThere are a variety of risk factors closely related to the intracranial infections in the severe cranial craniocerebral injury patients after emergency operation,it is necessary for the hospital to take targeted prevention countermeasures so as to effectively control the infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2013年第16期3903-3905,共3页
Chinese Journal of Nosocomiology
基金
贵州省省长基金(黔省专字[2012]106)
关键词
重型颅脑损伤
颅内感染
相关因素分析
Severe craniocerebral injury
Intracranial infection
Analysis of related factor
